S. Balducci, S. Zanuso, A. Nicolucci, F. Fernando, S. Cavallo et al., Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight toss, Nutr. Metab. Cardiovasc. Dis, vol.20, pp.608-617, 2010.

E. Bergman, U. , and B. , Loss of primary sensory neurons in the very old rat: neuron number estimates using the disector method and confocal optical sectioning, J. Comp. Neurol, vol.396, pp.211-222, 1998.

G. Caron, P. Decherchi, M. , and T. , Does metabosensitive afferent fibers activity differ from slow-and fast-twitch muscles? Exp, Brain Res, vol.233, pp.2549-2554, 2015.

G. Caron, T. Marqueste, and P. Decherchi, Restoration of post-activation depression of the H-reflex by treadmill exercise in aged rats, Neurobiol. Aging, vol.42, pp.61-68, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01454777

G. Caron, T. Rouzi, L. Grelot, G. Magalon, T. Marqueste et al., Mechano-and metabosensitive alterations after injection of botulinum toxin into gastrocnemius muscle, J. Neurosci. Res, vol.92, pp.904-914, 2014.

D. Ceballos, J. Cuadras, E. Verdu, and X. Navarro, Morphometric and ultrastructural changes with ageing in mouse peripheral nerve, J. Anat, vol.195, pp.563-576, 1999.

L. J. Cole, M. J. Farrell, S. J. Gibson, and G. F. Egan, Age-related differences in pain sensitivity and regional brain activity evoked by noxious pressure, Neurobiol. Aging, vol.31, pp.494-503, 2010.

J. A. Coull, D. Boudreau, K. Bachand, S. A. Prescott, F. Nault et al., Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain, Nature, vol.424, pp.938-942, 2003.

P. Decherchi, J. L. Darques, J. , and Y. , Modifications of afferent activities from tibialis anterior muscle in rat by tendon vibrations, increase of interstitial potassium or lactate concentration and electrically-induced fatigue, J. Peripher. Nerv. Syst, vol.3, pp.267-276, 1998.

P. Decherchi and E. Dousset, Role of metabosensitive afferent fibers in neuromuscular adaptive mechanisms]. Can, J. Neurol. Sci, vol.30, pp.91-97, 2003.
URL : https://hal.archives-ouvertes.fr/hal-01436190

P. Decherchi, E. Dousset, G. , and L. , Metabolic stability and physiological adaptation of muscle under conditions of exercise, Rev. Neurol, vol.160, pp.297-305, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00300588

P. Decherchi, E. Dousset, J. , and Y. , Respiratory and cardiovascular responses evoked by tibialis anterior muscle afferent fibers in rats, Exp. Brain Res, vol.183, pp.299-312, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00300609

P. Decherchi, G. Vuillon-cacciutolo, J. L. Darques, J. , and Y. , Changes in afferent activities from tibialis anterior muscle after nerve repair by self-anastomosis, Muscle Nerve, vol.24, pp.59-68, 2001.

M. R. Detloff, E. J. Smith, D. Q. Molina, P. D. Ganzer, and J. D. Houle, Acute exercise prevents the development of neuropathic pain and the sprouting of non-peptidergic (GDNF-and artemin-responsive) c-fibers after spinal cord injury, Exp. Neurol, vol.255, pp.38-48, 2014.

J. L. Dobson, J. Mcmillan, L. , and L. , Benefits of exercise intervention in reducing neuropathic pain, Front. Cell. Neurosci, vol.8, p.102, 2014.

E. Dousset, T. Marqueste, P. Decherchi, Y. Jammes, G. et al., Effects of neonatal capsaicin deafferentation on neuromuscular adjustments, performance, and afferent activities from adult tibialis anterior muscle during exercise, J. Neurosci. Res, vol.76, pp.734-741, 2004.
URL : https://hal.archives-ouvertes.fr/hal-01437533

R. R. Edwards, R. B. Fillingim, and T. J. Ness, Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults, Pain, vol.101, p.324, 2003.

C. M. Elitt, S. L. Mcilwrath, J. J. Lawson, S. A. Malin, D. C. Molliver et al., Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold, J. Neurosci, vol.26, pp.8578-8587, 2006.

Z. H. Gao, O. Henig, V. Kehoe, L. I. Sinoway, L. et al., Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats, J. Appl. Physiol, vol.100, pp.421-426, 2005.

Z. H. Gao, J. L. Li, L. I. Sinoway, L. , and J. H. , Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response, J. Appl. Physiol, vol.102, pp.2288-2293, 2007.

Y. Garcia-mesa, J. C. Lopez-ramos, L. Gimenez-llort, S. Revilla, R. Guerra et al., Physical exercise protects against Alzheimer's disease in 3xTg-AD mice, J. Alzheimers Dis, vol.24, pp.421-454, 2011.

J. L. Greaney, C. E. Schwartz, D. G. Edwards, P. J. Fadel, and W. B. Farquhar, The neural interaction between the arterial baroreflex and muscle metaboreflex is preserved in older men, Exp. Physiol, vol.98, pp.1422-1431, 2013.

A. Houssiere, B. Najem, A. Pathak, O. Xhaet, R. Naeije et al., Chemoreflex and metaboreflex responses to static hypoxic exercise in aging humans, Med. Sci. Sports Exerc, vol.38, pp.305-312, 2006.

G. A. Iwamoto and B. R. Botterman, Peripheral factors influencing expression of pressor reflex evoked by muscular-contraction, J. Appl. Physiol, vol.58, pp.1676-1682, 1985.
DOI : 10.1152/jappl.1985.58.5.1676

A. Kamiya, D. Michikami, T. Shiozawa, S. Iwase, J. Hayano et al., Bed rest attenuates sympathetic and pressor responses to isometric exercise in antigravity leg muscles in humans, Am. J. Physiol. Regul. Integr. Comp. Physiol, vol.286, 2004.
DOI : 10.1152/ajpregu.00497.2003

B. E. Keeler, G. Liu, R. N. Siegfried, V. Zhukareva, M. Murray et al., Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury, Brain Res, vol.1438, pp.8-21, 2012.

D. M. Koceja, E. Davison, and C. T. Robertson, Neuromuscular characteristics of endurance-and power-trained athletes, Res. Q. Exerc. Sport, vol.75, pp.23-30, 2004.

J. Laurin, E. Dousset, and P. Decherchi, Modulation of the spinal excitability by muscle metabosensitive afferent fibers, J. Neurosci. Res, vol.88, pp.2755-2764, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01436186

J. Laurin, V. Pertici, E. Dousset, T. Marqueste, and P. Decherchi, Group Iii and Iv muscle afferents: role on central motor drive and clinical implications, Neuroscience, vol.290, pp.543-551, 2015.
DOI : 10.1016/j.neuroscience.2015.01.065

URL : https://hal.archives-ouvertes.fr/hal-01436177

J. Lexell, Human aging, muscle mass, and fiber-type composition, J. Gerontol. Ser. Biol. Sci. Med. Sci, vol.50, pp.11-16, 1995.

J. Lexell, C. C. Taylor, and M. Sjostrom, What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15-to 83-year-old men, J. Neurol. Sci, vol.84, pp.275-294, 1988.

L. Li and J. M. Hondzinski, Select exercise modalities may reverse movement dysfunction because of peripheral neuropathy, Exerc. Sport Sci. Rev, vol.40, pp.133-137, 2012.

A. R. Light, R. W. Hughen, J. Zhang, J. Rainier, Z. Q. Liu et al., Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1, J. Neurophysiol, vol.100, pp.1184-1201, 2008.

T. A. Markel, J. C. Daley, C. S. Hogeman, M. D. Herr, M. H. Khan et al., Aging and the exercise pressor reflex in humans, Circulation, vol.107, pp.675-678, 2003.
DOI : 10.1161/01.cir.0000055190.81716.ab

URL : https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000055190.81716.AB

T. Marqueste, J. Alliez, O. Alluin, Y. Jammes, and P. Decherchi, Neuromuscular rehabilitation by treadmill running or electrical stimulation after peripheral nerve injury and repair, J. Appl. Physiol, vol.96, 1988.
DOI : 10.1152/japplphysiol.00775.2003

URL : https://hal.archives-ouvertes.fr/hal-00093854

V. Martin, E. Dousset, J. Laurin, J. Gondin, M. Gautier et al., , 2009.

, Group Iii and Iv muscle afferent discharge patterns after repeated lengthening and shortening actions, Muscle Nerve, vol.40, pp.827-837

S. B. Mazzone and D. P. Geraghty, Altered respiratory response to substance P and reduced NK1 receptor binding in the nucleus of the solitary tract of aged rats, Brain Res, vol.826, pp.139-142, 1999.

D. I. Mccloskey, M. , and J. H. , Reflex cardiovascular and respiratory responses originating in exercising muscle, J. Physiol, vol.224, pp.173-186, 1972.

S. Mense, Algesic agents exciting muscle nociceptors, Exp. Brain Res, vol.196, pp.89-100, 2009.
DOI : 10.1007/s00221-008-1674-4

J. H. Mitchell, W. C. Reardon, and D. I. Mccloskey, Reflex effects on circulation and respiration from contracting skeletal muscle, Am. J. Physiol, vol.233, pp.374-378, 1977.
DOI : 10.1152/ajpheart.1977.233.3.h374

M. N. Murphy, M. Mizuno, J. H. Mitchell, and S. A. Smith, Cardiovascular regulation by skeletal muscle reflexes in health and disease, Am. J. Physiol. Heart Circ. Physiol, vol.301, 2011.
DOI : 10.1152/ajpheart.00208.2011

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197431/pdf

B. Namer, Age related changes in human C-fiber function, Neurosci. Lett, vol.470, pp.185-187, 2010.

M. V. Narici, C. N. Maganaris, N. D. Reeves, C. , and P. , Effect of aging on human muscle architecture, J. Appl. Physiol, vol.95, pp.2229-2234, 2003.
DOI : 10.1152/japplphysiol.00433.2003

URL : http://jap.physiology.org/content/early/2003/07/03/japplphysiol.00433.2003.full.pdf

A. V. Ng, R. Callister, D. G. Johnson, and D. R. Seals, Sympathetic neural reactivity to stress does not increase with age in healthy humans, Am. J. Physiol, vol.267, pp.344-353, 1994.
DOI : 10.1152/ajpheart.1994.267.1.h344

O. E. Orozco, L. Walus, D. W. Sah, and M. Sanicola, GFRalpha3 is expressed predominantly in nociceptive sensory neurons, Eur. J. Neurosci, vol.13, pp.2177-2182, 2001.
DOI : 10.1046/j.0953-816x.2001.01596.x

E. Pasini, S. Le-douairon-lahaye, V. Flati, D. Assanelli, G. Corsetti et al., Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats, Exp. Gerontol, vol.47, pp.23-28, 2012.

D. M. Rotto and M. P. Kaufman, Effect of metabolic products of muscularcontraction on discharge of group-Iii and group-Iv afferents, J. Appl. Physiol, vol.64, pp.2306-2313, 1988.

A. Sato, Y. Sato, and H. Suzuki, Aging effects on conduction velocities of myelinated and unmyelinated fibers of peripheral-nerves, Neurosci. Lett, vol.53, pp.15-20, 1985.

S. K. Sidhu, J. C. Weavil, M. Venturelli, M. J. Rossman, B. S. Gmelch et al., Aging alters muscle reflex control of autonomic cardiovascular responses to rhythmic contractions in humans, Am. J. Physiol. Heart Circ. Physiol, vol.309, 2015.

S. A. Smith, R. M. Downey, J. W. Williamson, and M. Mizuno, Autonomic dysfunction in muscular dystrophy: a theoretical framework for muscle reflex involvement, Front. Physiol, vol.5, p.47, 2014.
DOI : 10.3389/fphys.2014.00047

URL : https://www.frontiersin.org/articles/10.3389/fphys.2014.00047/pdf

T. Taguchi and K. Mizumura, Augmented mechanical response of muscular thin-fiber receptors in aged rats recorded in vitro, Eur. J. Pain, vol.15, pp.351-358, 2011.

A. A. Vandervoort and A. J. Mccomas, Contractile changes in opposing muscles of the human ankle joint with aging, J. Appl. Physiol, vol.61, pp.361-367, 1986.

R. G. Victor, L. A. Bertocci, S. L. Pryor, and R. L. Nunnally, Sympatheticnerve discharge is coupled to muscle-cell Ph during exercise in humans, J. Clin. Invest, vol.82, pp.1301-1305, 1988.
DOI : 10.1172/jci113730

URL : http://www.jci.org/articles/view/113730/files/pdf

H. J. Wang, Y. L. Li, I. H. Zucker, W. , and W. , Exercise training prevents skeletal muscle afferent sensitization in rats with chronic heart failure, Am. J. Physiol. Regul. Integr. Comp. Physiol, vol.302, 2012.
DOI : 10.1152/ajpregu.00054.2012

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378347/pdf

S. Y. Wang, B. M. Davis, M. Zwick, S. G. Waxman, A. et al., Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice, Neurobiol. Aging, vol.27, pp.895-903, 2006.

J. C. Wilhelm, M. Xu, D. Cucoranu, S. Chmielewski, T. Holmes et al., Cooperative roles of BDNF expression in neurons and schwann cells are modulated by exercise to facilitate nerve regeneration, J. Neurosci, vol.32, pp.5002-5009, 2012.

L. B. Wilson, C. K. Dyke, D. Parsons, P. T. Wall, J. A. Pawelczyk et al., Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits, J. Appl. Physiol, vol.79, pp.1744-1752, 1995.

J. H. Xing, L. Sinoway, L. , and J. H. , Differential responses of sensory neurones innervating glycolytic and oxidative muscle to protons and capsaicin, J. Physiol. Lond, vol.586, pp.3245-3252, 2008.
DOI : 10.1113/jphysiol.2008.154450

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538781