Advances in the Use of Microfluidics to Study Crystallization Fundamentals

Abstract : This review compares droplet-based microfluidic systems used to study crystallization fundamentals in chemistry and biology. An original high-throughput droplet-based microfluidic platform is presented. It uses nL droplets, generates a "chemical library" and directly solubilizes powder, thus economizing both material and time. It is compatible with all solvents without the need for surfactant. Its flexibility permits phase diagram determination and crystallization studies (screening and optimizing experiments), and makes it easy to use for non-specialists in microfluidics. Moreover, it allows concentration measurement via UV spectroscopy and solid characterization via XRD analysis.
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Submitted on : Tuesday, December 18, 2018 - 4:18:22 PM
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Nadine Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler. Advances in the Use of Microfluidics to Study Crystallization Fundamentals. Annual Review of Chemical and Biomolecular Engineering, Annual Reviews, 2019, 10 (1), pp.59-83. ⟨10.1146/annurev-chembioeng-060718-030312⟩. ⟨hal-01959318⟩

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