Skip to Main content Skip to Navigation
Journal articles

Confinement-induced transition between wave-like collective cell migration modes:

Abstract : The structural and functional organization of biological tissues relies on the intricate interplay between chemical and mechanical signaling. Whereas the role of constant and transient mechanical perturbations is generally accepted, several studies recently highlighted the existence of longrange mechanical excitations (i.e., waves) at the supracellular level. Here, we confine epithelial cell mono-layers to quasi-one dimensional geometries, to force the establishment of tissue-level waves of well-defined wavelength and period. Numerical simulations based on a self-propelled Voronoi model reproduce the observed waves and exhibit a phase transition between a global and a multi-nodal wave, controlled by the confinement size. We con rm experimentally the existence of such a phase transition, and show that wavelength and period are independent of the confinement length. Together, these results demonstrate the intrinsic origin of tissue oscillations, which could provide cells with a mechanism to accurately measure distances at the supracellular level.
Document type :
Journal articles
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01958763
Contributor : Giovanni Cappello <>
Submitted on : Tuesday, December 18, 2018 - 11:18:52 AM
Last modification on : Tuesday, October 6, 2020 - 12:44:29 PM
Long-term archiving on: : Wednesday, March 20, 2019 - 12:11:20 PM

File

495747.full.pdf
Files produced by the author(s)

Identifiers

Collections

CNRS | CEA | DRT | LETI | UGA | CEA-GRE

Relations

  • is version of cea-02186440 - A effacer ou fusionner avec cea-02186440. Garder les métadonnées de cea-02186440 qui sont correctes.

Citation

Vanni Petrolli, Magali Le Goff, Monika Tadrous, Kirsten Martens, Cédric Allier, et al.. Confinement-induced transition between wave-like collective cell migration modes:. Physical Review Letters, American Physical Society, 2019, 122 (16), pp.168101. ⟨10.1103/PhysRevLett.122.168101⟩. ⟨hal-01958763⟩

Share

Metrics

Record views

271

Files downloads

445