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Pré-Publication, Document De Travail Année : 2018

HOW TO LIVE WITHOUT SEX: THE ANSWER OF CYTOPLASMIC GENOMES

Anne Atlan
Laurence D Hurst
  • Fonction : Auteur

Résumé

Uniparentally transmitted organelles are the best described anciently asexual genome and their analysis permits tests of models of the maintenance and long term consequences of sex. The genome size, copy number, substitution rate and topology of the organelle genomes of several different lineages are reviewed. These parameters appear not to be independent. Genome size is negatively correlated with substitution rate, copy number is positively correlated with substitution rate and genome size is negatively correlated with copy number. We note that this non-independence is consistent with the notion that for an asexual genome to persist, mutation accumulation, as envisaged for example in Muller's ratchet, must be slowed down. Cases where mutations do accumulate are also considered. Other mechanisms such as paternal contribution, the mode of transmission during cell division and RNA editing may also preserve the functionality of theses genomes. We show that mutational meltdown is a problem for genomes with uniparental inheritance, and that they develop different strategies to stay fit.
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Dates et versions

hal-01957601 , version 1 (17-12-2018)

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  • HAL Id : hal-01957601 , version 1

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Anne Atlan, Catherine Boyen, Laurence D Hurst. HOW TO LIVE WITHOUT SEX: THE ANSWER OF CYTOPLASMIC GENOMES. 2018. ⟨hal-01957601⟩
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