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Article Dans Une Revue Polymer Chemistry Année : 2018

Cd2+ coordination: An efficient structuring switch for polypeptide polymers

Résumé

Stimuli-responsive polypeptides have practical applications in devices and therapeutic delivery. Here we report that coordination to Cd2+ metal species can be used as a robust stimulus to control both, α-helix and β-sheet secondary structuring of polypeptide polymers whose metal responsiveness was achieved in the presence of a competitive buffer. As evidenced by circular dichroism analyses, secondary structuring can be easily reversed using “sequestering” external ligands, such as EDTA, that are widely used in industry, to finally design a multivalent polypeptide backbone combining metal responsiveness to two other stimuli, pH and redox conditions.
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Dates et versions

hal-01954195 , version 1 (13-12-2018)

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Julien Aujard-Catot, Michel Nguyen, Christian Bijani, Geneviève Pratviel, Colin Bonduelle. Cd2+ coordination: An efficient structuring switch for polypeptide polymers. Polymer Chemistry, 2018, 9 (30), pp.4100-4107. ⟨10.1039/C8PY00810H⟩. ⟨hal-01954195⟩
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