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Article Dans Une Revue Photochemical & Photobiological Sciences Année : 2018

Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Résumé

The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER− and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.

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Chimie Autre
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Dates et versions

hal-01950232 , version 1 (14-11-2021)

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Huguette Savoie, Carlotta Figliola, Estelle Marchal, Bry W. Crabbe, Geniece L. Hallett-Tapley, et al.. Photo-induced anticancer activity and singlet oxygen production of prodigiosenes. Photochemical & Photobiological Sciences , 2018, ⟨10.1039/C8PP00060C⟩. ⟨hal-01950232⟩
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