[N,P]-pyrrole-phosphine ligand: An efficient and robust ligand for Ru-catalyzed transfer hydrogenation microwave-assisted reactions

E. P. Sanchez-Rodriguez (1) , A. J. Fragoso-Medina (1) , E. Ramírez-Meneses (2) , Maryse Gouygou (3, 4) , M. C. Ortega-Alfaro (5) , J. G. Lopez-Cortes (1)

1 Instituto de Quı́mica, Universidad Nacional Autónoma de México
2 Departamento de Ingeniería y Ciencias Químicas Universidad Iberoamericana
3 LCC - Laboratoire de chimie de coordination
4 Toulouse INP - Institut National Polytechnique (Toulouse)
5 Instituto de Ciencias Nucleares, UNAM

A pyrrolyl-containing [N-P]-ligand (L1) and [Ru] were evaluated as catalytic system in transfer hydrogenation reaction of ketones. A comparison between microwave irradiation vs conventional heating conditions indicates that MW can be successfully used as energy source, improving the reaction time. The L1/Ru(II) proved to be an active, efficient and robust catalytic system. The scope of this catalytic system was evaluated using a diversity of substrates that include electron-withdrawing and electron-donor groups achieving a range of 65 to 95% conversion. Moreover, the catalytic system showed good activity even with highly sterically hindered ketones.

Domaines: Chimie de coordination

E. P. Sanchez-Rodriguez, A. J. Fragoso-Medina, E. Ramírez-Meneses, Maryse Gouygou, M. C. Ortega-Alfaro, et al.. [N,P]-pyrrole-phosphine ligand: An efficient and robust ligand for Ru-catalyzed transfer hydrogenation microwave-assisted reactions. Catalysis Communications, 2018, 115, pp.49-54. ⟨10.1016/j.catcom.2018.07.009⟩. ⟨hal-01949858⟩