Phenotypic effects of concomitant insensitive acetylcholinesterase (ace-1 R ) and knockdown resistance (kdr R ) in Anopheles gambiae: a hindrance for insecticide resistance management for malaria vector control

Benoît S Assogba (1, 2) , Luc Djogbénou (3) , Jacques Saizonou (3) , Pascal Milesi (1) , Laurette Djossou (3) , Innocent Djègbé (4, 5) , Welbeck Oumbouke (5) , Fabrice Chandre (6) , Lamine S Baba-Moussa (3) , Mylene Weill (1) , Michel Makoutodé (2)

1 UMR ISEM - Institut des Sciences de l'Evolution de Montpellier
2 UAC - Université d’Abomey-Calavi = University of Abomey Calavi
3 LBBM - Laboratoire de Biochimie et de Biologie Moléculaire (Université d'Abomey Calavi, Cotonou, Bénin)
4 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
5 CREC - Centre de Recherche Entomologique de Cotonou
6 MIVEGEC-VCG - Vector Control Group

Malaria is endemic in sub-Saharan Africa with considerable burden for human health. Major insecticide resistance mechanisms such as kdr(R) and ace-1(R) alleles constitute a hindrance to malaria vector control programs. Anopheles gambiae bearing both kdr and ace-1 resistant alleles are increasingly recorded in wild populations. In order to maintain the efficacy of vector control strategies, the characterization of concomitant kdr and ace-1 resistance, and their pleiotropic effects on malaria vector phenotype on insecticide efficacy are important.

Mots clés: Anopheles gambiae; Insecticide resistance genes; Concomitant effects; Malaria; Vector control

Domaines: Sciences de l'environnement; Biodiversité et Ecologie

Benoît S Assogba, Luc Djogbénou, Jacques Saizonou, Pascal Milesi, Laurette Djossou, et al.. Phenotypic effects of concomitant insensitive acetylcholinesterase (ace-1 R ) and knockdown resistance (kdr R ) in Anopheles gambiae: a hindrance for insecticide resistance management for malaria vector control. Parasites & Vectors, 2014, 7 (1), pp.548. ⟨10.1186/s13071-014-0548-9⟩. ⟨hal-01944547⟩