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Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming.

Abstract : Plants have become, over the last ten years, a suitable alternative to microbial and animal cell factories for the production of clinically-useful, therapeutic proteins. Besides the well known advantage of low-cost and large-scale production of safe and biologically active mammalian proteins, plants also are able to perform most post-translational maturations required for biological activity and suitable pharmacokinetics of recombinant therapeutic proteins. In this short review we focus on glycosylation and proteolytic processing of plant-made pharmaceuticals during their transport through the plant cell's secretory pathway. We also address the practical implications of these important processes on the effectiveness of plant molecular pharming systems.
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https://hal.archives-ouvertes.fr/hal-01942853
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Submitted on : Monday, December 3, 2018 - 2:53:36 PM
Last modification on : Tuesday, October 19, 2021 - 4:13:57 PM

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Loic Faye, Aurélia Boulaflous, Meriem Benchabane, Veronique Gomord, Dominique Michaud. Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming.. Vaccine, Elsevier, 2005, 23 (15), pp.1770-8. ⟨10.1016/j.vaccine.2004.11.003⟩. ⟨hal-01942853⟩

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