Efficient extraction method using magnetic carbon nanotubes to analyze cocaine and benzoylecgonine in breast milk by GC/MS

R. Resende dos Santos (1) , M. J. Nunes Paiva (2) , J. C. Veloso (2) , Philippe Serp (3, 4) , Z. De Lourdes Cardeal (1) , H. C. Menezes (1)

1 Departamento de Química, Universidade Federal de Minas Gerais
2 Departamento de Farmácia, Universidade Federal de São João Del-Rei
3 LCC - Laboratoire de chimie de coordination
4 Toulouse INP - Institut National Polytechnique (Toulouse)

Aim: The increasing use of cocaine (COC) during breastfeeding has led to growing concern about exposure of infants. Therefore, to study this exposure, a new method to analyze COC and benzoylecgonine in breast milk was developed. Methodology: A new extraction method was used for the first time to analyze COC and its major metabolite, benzoylecgonine, in breast milk using magnetic carbon nanotubes partially doped with nitrogen. Results: The calibration curves were linear in the range 5.0–180.0 ng ml-1. The limit of quantification was 5.0 ng ml-1. Coefficients of variation were between 3.2 and 13.9%. Recovery was between 89.6 and 99.2%. Conclusion: The proposed method is simple, efficient and suitable to determine analytes in breast milk.

Domaines: Chimie de coordination

R. Resende dos Santos, M. J. Nunes Paiva, J. C. Veloso, Philippe Serp, Z. De Lourdes Cardeal, et al.. Efficient extraction method using magnetic carbon nanotubes to analyze cocaine and benzoylecgonine in breast milk by GC/MS. Bioanalysis, 2017, 9 (21), pp.1655-1666. ⟨10.4155/bio-2017-0140⟩. ⟨hal-01939183⟩