Activity of 2,4-Di-tert-butylphenol produced by a strain of Streptomyces mutabilis isolated from a Saharan soil against Candida albicans and other pathogenic fungi

S. Beighit (1) , E. H. Driche (1) , Christian Bijani (2) , Abdelkrim Zitouni (1) , N. Sabaou (1) , B. Badji (1) , Florence Mathieu (3)

1 Laboratoire de Biologie des Systèmes Microbiens - LBSM (Alger, Algeria)
2 LCC - Laboratoire de chimie de coordination
3 LGC - Laboratoire de Génie Chimique

In a search for new antifungal antibiotics active against Candida albicans and others pathogenic fungi, a strain of actinobacteria, designated G61, was isolated from a Saharan soil and tested for its activity against these microorganisms. The analysis of its 16S rDNA sequence showed a similarity level of 100% with Streptomyces mutabilis NBRC 12800T. The highest anticandidal activities produced by the strain G61 were obtained on Bennett medium in the fourth day of incubation. The active product, extracted by n-butanol, contained one bioactive spot detected on thin layer chromatography plates. It was purified by HPLC and its chemical structure was determined by spectroscopic analyses as 2,4-Di-tert-butylphenol. The minimum inhibitory concentrations (MIC) of this product against several strains of pathogenic microorganisms are interesting.

Mots clés: Streptomyces; Taxonomy; Antifungal activity; Candida albicans; 2; 4-Di-tert-butylphenol

Domaines: Génie chimique; Génie des procédés

S. Beighit, E. H. Driche, Christian Bijani, Abdelkrim Zitouni, N. Sabaou, et al.. Activity of 2,4-Di-tert-butylphenol produced by a strain of Streptomyces mutabilis isolated from a Saharan soil against Candida albicans and other pathogenic fungi. Journal of Medical Mycology = Journal de Mycologie Médicale, 2016, 26 (2), pp.160-169. ⟨10.1016/j.mycmed.2016.03.001⟩. ⟨hal-01938085⟩