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Article Dans Une Revue Birth Defects Research Part A: Clinical and Molecular Teratology Année : 2010

Fetal skin fibroblasts: A cell model for studying the retinoid pathway in congenital diaphragmatic hernia

Résumé

Although there is strong evidence that genetic factors play a pathogenic role in congenital diaphragmatic hernia (CDH), few causal genes have been identified in humans. A number of studies, essentially in animal models, have suggested that disruption of the retinoid signaling pathway plays a major role in the pathogenesis of CDH. Our hypothesis is that human fetal skin fibroblasts express some metabolic and molecular actors of the retinoid pathway and that they offer convenient cellular material for investigating the molecular retinoid pathway defects associated with CDH.

Dates et versions

hal-01927214 , version 1 (19-11-2018)

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Carole Goumy, Karen Coste, Geoffroy Marceau, Laetitia Gouas, Andrei Tchirkov, et al.. Fetal skin fibroblasts: A cell model for studying the retinoid pathway in congenital diaphragmatic hernia. Birth Defects Research Part A: Clinical and Molecular Teratology, 2010, pp.NA - NA. ⟨10.1002/bdra.20647⟩. ⟨hal-01927214⟩
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