Evaluation of biological effectiveness of 65 MeV therapeutic proton beams using the GATE platform

Yasmine Ali (1) , Françoise Degoul (2) , Eric Debiton (2) , Joël Hérault (3) , Marie Vidal (3) , Lydia Maigne (1)

1 LPC - Laboratoire de Physique de Clermont
2 IMoST - Imagerie Moléculaire et Stratégies Théranostiques
3 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]

Introduction: In order to optimize hadrontherapy treatments, it is needed to consider the biological effect on irradiated tumor cells. The biological dose can be evaluated through biophysical models, such as the Microdosimetric Kinetic Model (MKM)[1-5]. This model is implemented to take into account a corrected lineal energy spectrum obtained from Monte Carlo simulations and the model parameters of irradiated cells obtained from experiments. The purpose of this study is to validate the implementation of the MKM model into GATE through the simulation of the 65 MeV therapeutic proton beam (MediCyc) of Antoine Lacassagne centre for the estimation of the relative biological effectiveness (RBE).

Domaines: Modélisation et simulation; Physique Médicale [physics.med-ph]

Yasmine Ali, Françoise Degoul, Eric Debiton, Joël Hérault, Marie Vidal, et al.. Evaluation of biological effectiveness of 65 MeV therapeutic proton beams using the GATE platform. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-01926849⟩