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Subspecialization within default mode nodes characterized in 10,000 UK Biobank participants

Abstract : The human default mode network (DMN) is implicated in several unique mental capacities. In this study, we tested whether brain-wide inter-regional communication in the DMN can be derived from population variability in intrinsic activity fluctuations, grey-matter morphology and fiber-tract anatomy. In a sample of 10,000 UK Biobank participants, pattern-learning algorithms revealed functional coupling states in the DMN that are linked to connectivity profiles between other macroscopical brain networks. In addition, DMN greymatter volume was covaried with white-matter microstructure of the fornix. Collectively, functional and structural patterns unmasked a possible division of labor within major DMN nodes: subregions most critical for cortical network interplay were adjacent to subregions most predictive of fornix fibers from the hippocampus that processes memories and places.
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Submitted on : Monday, November 19, 2018 - 2:39:21 PM
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Julius Kernbach, B Yeo, Jonathan Smallwood, Daniel Margulies, Michel Thiebaut de Schotten, et al.. Subspecialization within default mode nodes characterized in 10,000 UK Biobank participants. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2018, ⟨10.1073/pnas.1804876115⟩. ⟨hal-01926796⟩



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