Transition-Metal-Free Synthesis of Biarylmethanes from Aryl Iodides and Benzylic Ketones

Martin Pichette drapeau (1) , Anis Tlili (2) , Yassir Zaid , Dounia Toummini (2) , Fouad Ouazzani chahdi , Jean-Marc Sotiropoulos (3) , Thierry Ollevier (4) , Marc Taillefer (2)

1 RUB - Ruhr University Bochum = Ruhr-Universität Bochum
2 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
3 IPREM - Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux
4 ULaval - Université Laval [Québec]

An original metal-free procedure for the synthesis of biarylmethanes is disclosed herein. The reactions occur with high selectivity starting from aryl iodides and benzylic ketones in the presence of superbasic media (CsOH/DMSO). This procedure allows a straightforward access to a wide range of biarylmethane derivatives substituted with electron-withdrawing and -donating substituents.

Mots clés: C−C coupling; biarylmethanes; ketones; superbase; metal-free

Domaines: Chimie théorique et/ou physique; Chimie analytique; Polymères; Matériaux

Martin Pichette drapeau, Anis Tlili, Yassir Zaid, Dounia Toummini, Fouad Ouazzani chahdi, et al.. Transition-Metal-Free Synthesis of Biarylmethanes from Aryl Iodides and Benzylic Ketones. Chemistry - A European Journal, 2018, 24 (17449), ⟨10.1002/chem.201804415⟩. ⟨hal-01925977⟩