Absence of a High Level of Duplication of the Plasmepsin Gene in Africa

Marie Gladys Robert , Francis Foguim Tsombeng , Mathieu Gendrot (1, 2) , Joel Mosnier (3, 4) , Remy Amalvict (4) , Nicolas Benoit , Marylin Torrentino-Madamet (5, 4) , Bruno Pradines (4) , French Natl Reference Ctr Imported

1 IRBA - Institut de Recherche Biomédicale des Armées [Antenne Marseille]
2 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
3 Service de Biochimie
4 VITROME - Vecteurs - Infections tropicales et méditerranéennes
5 Unité de Recherche en Biologie et Epidémiologie Parasitaires

Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine reduced susceptibility in Africa. Additionally, the few isolates with reduced susceptibility to piperaquine did not harbor amplification of the plasmepsin II gene.

Domaines: Maladies infectieuses

Marie Gladys Robert, Francis Foguim Tsombeng, Mathieu Gendrot, Joel Mosnier, Remy Amalvict, et al.. Absence of a High Level of Duplication of the Plasmepsin Gene in Africa. Antimicrobial Agents and Chemotherapy, 2018, 62 (11), ⟨10.1128/AAC.00374-18⟩. ⟨hal-01924107⟩