Early events induced by the toxin deoxynivalenol lead to programmed cell death in Nicotiana tabacum cells

Abstract : Deoxynivalenol (DON) is a mycotoxin affecting animals and plants. This toxin synthesized by Fusarium culmorum and Fusarium graminearum is currently believed to play a decisive role in the fungal phytopathogenesis as a virulence factor. Using cultured cells of Nicotiana tabacum BY2, we showed that DON-induced programmed cell death (PCD) could require transcription and translation processes, in contrast to what was observed in animal cells. DON could induce different cross-linked pathways involving (i) reactive oxygen species (ROS) generation linked, at least partly, to a mitochondrial dysfunction and a transcriptional down-regulation of the alternative oxidase (Aox1) gene and (ii) regulation of ion channel activities participating in cell shrinkage, to achieve PCD.
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Amine Yekkour, Daniel Tran, Delphine Arbelet-Bonnin, Joël Briand, Florence Mathieu, et al.. Early events induced by the toxin deoxynivalenol lead to programmed cell death in Nicotiana tabacum cells. Plant Science, Elsevier, 2015, 238, pp.148-157. ⟨10.1016/j.plantsci.2015.06.004⟩. ⟨hal-01917337⟩

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