Skip to Main content Skip to Navigation
Journal articles

Chitin Nanoforms Provide Mechanical and Topological Cues to Support Growth of Human Adipose Stem Cells in Chitosan Matrices

Abstract : The precise role and value of incorporating nanoforms in biologically active matrices for medical applications is not known. In our current work, we incorporate two chitin nanoforms (i.e., nanocrystals or nanofibers) into Genipin-chitosan crosslinked matrices. These materials were studied as 2D films and 3D porous scaffolds to assess their potential as primary support and guidance for stem cells in tissue engineering and regenerative medicine applications. The incorporation of either nanoforms in these 2D and 3D materials reveals significantly better swelling properties and robust mechanical performance in contrast to nanoform-free chitosan matrices. Furthermore, our data shows that these materials, in particular, incorporation of low concentration chitin nanoforms provide specific topological cues to guide the survival, adhesion, and proliferation of human adipose-derived stem cells. These findings demonstrate the potential of Genipin-chitosan crosslinked matrices impregnated with chitin nanoforms as value added materials for stem cell-based biomedical applications.
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-01915671
Contributor : Sylvie Blanc Connect in order to contact the contributor
Submitted on : Wednesday, November 7, 2018 - 7:14:25 PM
Last modification on : Tuesday, January 4, 2022 - 4:06:32 AM

Identifiers

Collections

Citation

Verónica Zubillaga, Asier Salaberria, Teodoro Palomares, Ana Alonso-Varona, Sujit Kootala, et al.. Chitin Nanoforms Provide Mechanical and Topological Cues to Support Growth of Human Adipose Stem Cells in Chitosan Matrices. Biomacromolecules, American Chemical Society, 2018, 19 (7), pp.3000 - 3012. ⟨10.1021/acs.biomac.8b00570⟩. ⟨hal-01915671⟩

Share

Metrics

Record views

30