Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs

Marwa Ben Ali Gannoun (1) , Hedia Zitouni (1) , Nozha Raguema (1) , Wided Maleh (1) , Jean-Christophe Gris (2, 3) , Wassim Almawi (4) , Touhami Mahjoub (1)

1 UM - Université de Monastir - University of Monastir
2 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
3 EA 2992 - Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires
4 Arabian Gulf University

We investigated the association of endothelial nitric oxide synthase (NOS3) polymorphisms -786T>C, 27-bp repeat 4b/4a, and Glu298Asp with preeclampsia (PE). This was a case-control study involving 345 unrelated Tunisian women with PE and 289 unrelated age- and ethnically matched control women. The -786C allele was significantly increased in PA patients when compared to healthy controls (P=0.015). In contrast, MAF of Glu298Asp (P=0.103) and 4b/4a (P=0.168) were not significantly different between the study groups. Higher frequencies of heterozygous Glu298/298Asp and homozygous -786T/-786T genotypes were seen in PE cases compared to healthy subjects. The combination of genotypes 221 (-786T>C, Glu298Asp, 4a/4a) was more in PE cases compared with control women (17.68% vs. 8.36%; P=0.029). Multivariate regression analysis confirmed this association. Genetic variation at the NOS3 locus represents a genetic risk factor for increased susceptibility to PE.

Mots clés: Nitric oxide; Polymorphism; Preeclampsia

Domaines: Génétique humaine

Marwa Ben Ali Gannoun, Hedia Zitouni, Nozha Raguema, Wided Maleh, Jean-Christophe Gris, et al.. Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs. Gene, 2015, 569 (2), pp.303 - 307. ⟨10.1016/j.gene.2015.05.072⟩. ⟨hal-01914840⟩