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Article Dans Une Revue Anaesthesia Critical Care & Pain Medicine Année : 2015

Neuron specific enolase and Glasgow motor score remain useful tools for assessing neurological prognosis after out-of-hospital cardiac arrest treated with therapeutic hypothermia

Résumé

AIM OF THE STUDY: Identifying clinical, electrophysiological and biological predictors for 6-month neurological outcome in survivors at day 3 after cardiac arrest (CA) treated with therapeutic hypothermia (TH). METHODS: We conducted a retrospective cohort study of adults comatose after out-of hospital CA treated with TH. All data were collected from medical charts and laboratory files. RESULTS: Between January 2010 and March 2013, among the 130 analysed CA survivors, 27 (21%) had a good neurological outcome at 6 months and 103 (79%) had a poor neurological outcome, including 98 deaths. The Glasgow coma score motor response (GCS-M), pupillary reflexes and Neuron Specific Enolase (NSE) were the three best predictors of neurological outcome (P<0.0001). The area under the Receiver Operating Characteristic curve for NSE was 0.92 [0.84-0.99]. CONCLUSION: NSE values, GCS-M scores and pupillary reflexes are the best predictors of poor 6-month outcome after out-of-hospital CA treated with TH. Of these, NSE values have the best-isolated prognostic performance when above 28.8μg/L.
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hal-01913267 , version 1 (06-11-2018)

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Claire Roger, Ludovic Palmier, Benjamin Louart, Nicolas Molinari, Pierre-Géraud Claret, et al.. Neuron specific enolase and Glasgow motor score remain useful tools for assessing neurological prognosis after out-of-hospital cardiac arrest treated with therapeutic hypothermia. Anaesthesia Critical Care & Pain Medicine, 2015, 34 (4), pp.231 - 237. ⟨10.1016/j.accpm.2015.05.004⟩. ⟨hal-01913267⟩
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