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Atypical stress response to temperature and NaOCl exposure leading to septation defect during cell division in Cupriavidus metallidurans CH34
Abstract : Cupriavidus metallidurans CH34 has long been known for its temperature-induced mutagenesis and mortality phenotype (TIMM), for which a genetic origin has been suggested repeatedly. In this report, we present microscopic-based evidences that the TIMM process actually starts with a septation defect, leading to aberrant cell morphologies. Moreover, the septation defect of CH34 could be induced by NaOCl, thus showing that the TIMM phenotype may be part of a more general stress response. Sequence analysis of a TIMM survivor exhibiting a recurrent recognizable lysA mutation ruled out the possibility of a genetic ground linking TIMM survival and peptidoglycan synthesis.
https://hal.archives-ouvertes.fr/hal-01912959
Contributor : Laurence Mathieu Connect in order to contact the contributor
Submitted on : Monday, November 5, 2018 - 6:00:44 PM
Last modification on : Thursday, December 9, 2021 - 2:54:07 PM
Contributor : Laurence Mathieu Connect in order to contact the contributor
Submitted on : Monday, November 5, 2018 - 6:00:44 PM
Last modification on : Thursday, December 9, 2021 - 2:54:07 PM
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