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Atypical stress response to temperature and NaOCl exposure leading to septation defect during cell division in Cupriavidus metallidurans CH34

Abstract : Cupriavidus metallidurans CH34 has long been known for its temperature-induced mutagenesis and mortality phenotype (TIMM), for which a genetic origin has been suggested repeatedly. In this report, we present microscopic-based evidences that the TIMM process actually starts with a septation defect, leading to aberrant cell morphologies. Moreover, the septation defect of CH34 could be induced by NaOCl, thus showing that the TIMM phenotype may be part of a more general stress response. Sequence analysis of a TIMM survivor exhibiting a recurrent recognizable lysA mutation ruled out the possibility of a genetic ground linking TIMM survival and peptidoglycan synthesis.
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https://hal.archives-ouvertes.fr/hal-01912959
Contributor : Laurence Mathieu Connect in order to contact the contributor
Submitted on : Monday, November 5, 2018 - 6:00:44 PM
Last modification on : Thursday, December 9, 2021 - 2:54:07 PM

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Boussad Arroua, Xavier Bellanger, Hélène Guilloteau, Laurence Mathieu, Christophe Merlin. Atypical stress response to temperature and NaOCl exposure leading to septation defect during cell division in Cupriavidus metallidurans CH34. FEMS Microbiology Letters, Wiley-Blackwell, 2014, 353 (1), pp.33 - 39. ⟨10.1111/1574-6968.12399⟩. ⟨hal-01912959⟩

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