Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates

Fabien Pifferi (1) , Jérémy Terrien (1) , Marc Marchal (1) , Alexandre Dal-Pan (1) , Fathia Djelti (1) , Isabelle Hardy (1) , Sabine Chahory (2) , Nathalie Cordonnier-Lefort (3) , Loic Desquilbet (2, 1) , Murielle Hurion (3) , Alexandre Zahariev (4) , Isabelle Chery (4) , Philippe Zizzari (5) , Martine Perret (1) , Jacques Epelbaum (1, 5) , Stéphane Blanc (4) , Jean-Luc Picq (6, 7, 8) , Marc Dhenain (7, 8) , Fabienne Aujard (1)

1 MECADEV - Mécanismes Adaptatifs et Evolution
2 ENVA - École nationale vétérinaire d'Alfort
3 Ecole Nationale Vétérinaire d’Alfort, Unité d’anatomie pathologique
4 DEPE-IPHC - Département Ecologie, Physiologie et Ethologie
5 U894 - Centre de Psychiatrie et Neurosciences
6 LPN - Laboratoire de Psychopathologie et Neuropsychologie
7 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
8 CEA - Commissariat à l'énergie atomique et aux énergies alternatives

The health benefits of chronic caloric restriction resulting in lifespan extension are wellestablished in many short-lived species, but the effects in humans and other primates remaincontroversial. Here we report the most advanced survival data and the associated follow-upto our knowledge of age-related alterations in a cohort of grey mouse lemurs (Microcebusmurinus, lemurid primate) exposed to a chronic moderate (30%) caloric restriction. Comparedto control animals, caloric restriction extended lifespan by 50% (from 6.4 to 9.6 years,median survival), reduced aging-associated diseases and preserved loss of brain white matterin several brain regions. However, caloric restriction accelerated loss of grey matterthroughout much of the cerebrum. Cognitive and behavioural performances were, however,not modulated by caloric restriction. Thus chronic moderate caloric restriction can extendlifespan and enhance health of a primate, but it affects brain grey matter integrity withoutaffecting cognitive performances.

Domaines: Sciences de l'environnement

Fabien Pifferi, Jérémy Terrien, Marc Marchal, Alexandre Dal-Pan, Fathia Djelti, et al.. Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates. Communications Biology, 2018, 1 (1), ⟨10.1038/s42003-018-0024-8⟩. ⟨hal-01912059⟩