Analysis of interaction between telomeric i-motif DNA and a cyclic tetraoxazole compound

Shadi Sedghi Masoud (1) , Yudai Yamaoki (2) , Yue Ma (1) , Adrien Marchand (3) , Fernando Richtia Winnerdy (4) , Valérie Gabelica (3) , Anh Tuân Phan (4) , Masato Katahira (2) , Kazuo Nagasawa (1)

1 TUAT - Tokyo University of Agriculture and Technology
2 Kyoto University
3 ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle
4 Nanayang Technological University

The interaction of a macrocyclic tetraoxazole compound, L2H2‐4OTD (1), with two aminoalkyl side chains and telomeric i‐motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i‐motif structure at two preferred binding sites.

Domaines: Toxicologie; Biologie structurale [q-bio.BM]; Biophysique [physics.bio-ph]; Biochimie [q-bio.BM]

Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrien Marchand, Fernando Richtia Winnerdy, et al.. Analysis of interaction between telomeric i-motif DNA and a cyclic tetraoxazole compound. ChemBioChem, 2018, 39 (21), pp.2268-2272. ⟨10.1002/cbic.201800425⟩. ⟨hal-01910151v2⟩