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Ultra-low-dose chest CT with iterative reconstruction does not alter anatomical image quality

Abstract : PURPOSE: To evaluate the effect of dose reduction with iterative reconstruction (IR) on image quality of chest CT scan. MATERIALS AND METHODS: Eighteen human cadavers had chest CT with one reference CT protocol (RP-CT; 120kVp/200mAs) and two protocols with dose reduction: low-dose-CT (LD-CT; 120kVp/40mAs) and ultra-low-dose CT (ULD-CT; 120kVp/10mAs). Data were reconstructed with filter-back-projection (FBP) for RP-CT and with FBP and IR (sinogram affirmed iterative reconstruction [SAFIRE®]) algorithm for LD-CT and ULD-CT. Volume CT dose index (CTDIvol) were recorded. The signal-to-noise (SNR), contrast-to-noise (CNR) ratios of LD-CT and ULD-CT and quantitative parameters were compared to RP-CT. Two radiologists reviewed the CT examinations assessed independently the quality of anatomical structures and expressed a confidence level using a 2-point scale (50% and 95%). RESULTS: CTDIvol was 2.69 mGy for LD-CT (-80%; P<0.01) and 0.67 mGy for ULD-CT (-95%; P<0.01) as compared to 13.42 mGy for RP-CT. SNR and CNR were significantly decreased (P<0.01) for LD-CT and ULD-CT, but IR improved these values satisfactorily. No significant differences were observed for quantitative measurements. Radiologists rated excellent/good the RP-CT and LD-CT images, whereas good/fair the ULD-CT images. Confidence level for subjective anatomical analysis was 95% for all protocols. CONCLUSIONS: Dose reduction with a dose lower than 1 mGy, used in conjunction with IR allows performing chest CT examinations that provide a high quality of anatomical structures.
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Submitted on : Wednesday, October 24, 2018 - 3:19:35 PM
Last modification on : Tuesday, March 15, 2022 - 9:39:02 AM

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F. Macri, J. Greffier, F. Pereira, C. Mandoul, E. Khasanova, et al.. Ultra-low-dose chest CT with iterative reconstruction does not alter anatomical image quality. Diagnostic and Interventional Imaging, Elsevier, 2016, 97 (11), pp.1131 - 1140. ⟨10.1016/j.diii.2016.06.009⟩. ⟨hal-01903686⟩

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