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Les microbiotes transférés de la mère à l’enfant jouent-t-ils un rôle dans l’origine développementale de la santé et des maladies ? : Do microbiota transferred from mother to child pay a role in the developmental origine of health an disease?

Abstract : The idea that the mother's diet and her metabolic state can significantly influence the health of her offspring, by acting primarily on fetal growth and then creating a breeding ground for the emergence of metabolic diseases, has emerged thanks to work of the English epidemiologist Dr. David Barker. The concept of the developmental origin of health and disease (DOHaD) has been confirmed by a large number of experimental studies on animal models and has been extended to a number of pathologies. In particular, it has been shown that parents (and grandparents) nutrition and metabolic state at the time of conception guide the metabolic outcome and the feeding behavior of the offspring (Parnet et al., 2016). Since these works, a new key player has emerged: the microbiota, together with an important question: what is the impact of the vertical transfer (from mother to child) of microbiota on the child’s health? Can the intestinal microbiota be a relay or a memory of the parents' health and play a role in the developmental origin of health and diseases of the child? If so, what are the mechanistic and intervention tracks?
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https://hal.archives-ouvertes.fr/hal-01899860
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Submitted on : Friday, October 19, 2018 - 8:06:30 PM
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Patricia Parnet, Catherine Michel, Anne-Lise Pocheron, Valérie Amarger, Gwenola Le Drean. Les microbiotes transférés de la mère à l’enfant jouent-t-ils un rôle dans l’origine développementale de la santé et des maladies ? : Do microbiota transferred from mother to child pay a role in the developmental origine of health an disease?. Innovations Agronomiques, INRAE, 2018, 65, pp.1-14. ⟨10.15454/1.5408031448739663E12⟩. ⟨hal-01899860⟩

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