Microfluidics set-up rapidly measures solubility directly from powder

Guillem Peybernès (1) , Romain A Grossier (1) , Frédéric Villard (2) , Philippe Letellier (2) , Mehdi Lagaize (1) , Nadine A Candoni (1) , Stéphane Veesler (1)

1 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille
2 Technologies Servier

This communication presents a new microfluidics device for solubility measurement based on the generation of saturated solutions starting from powder and compatible with all solvents and molecules. This device is simple and easily incorporated into any laboratory, even those not specialized in microfluidics. We described the method used to measure solubility, applied here to the pharmaceutical molecules paracetamol and gliclazide in different solvents. The device rapidly measures the solubility of a compound at a variety of temperatures ranging from 20 to 60°C using extremely small quantities (here, only 30mg) of material, with a concentration range from mg/mL to hundreds of mg/mL.

Mots clés: Solubility; Crystallization; Microfluidics; Pharmaceutical molecules

Domaines: Science des matériaux [cond-mat.mtrl-sci]; Génie des procédés; Pharmacie galénique

Guillem Peybernès, Romain A Grossier, Frédéric Villard, Philippe Letellier, Mehdi Lagaize, et al.. Microfluidics set-up rapidly measures solubility directly from powder. Organic Process Research and Development, 2018, 22, pp.1856-1860. ⟨10.1021/acs.oprd.8b00300⟩. ⟨hal-01899746v2⟩