Discovery of Eco-Compatible Synthetic Paths by a Multi-Catalysis Approach

Jean Rodriguez (1) , Adrien Quintard (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

This article summarizes our recent developments in the discovery of multi-catalytic reactions. By efficiently taking the best from different worlds, the combination of several catalytic principles allows the invention of eco-compatible transformations rapidly assembling simple building blocks into elaborated enantioenriched molecules. This type of approach was successfully illustrated in the synthesis of cyclohexenones, keto-diols or in the direct functionalization of allylic alcohols by an enantioselective borrowing hydrogen. In addition, mechanistic understanding of the role of the different constituents enabled the fine-tuning of the catalytic systems considerably improving the efficiency notably in terms of enantiocontrol.

Mots clés: Organocatalysis; metal catalysis; Multi-catalysis; copper catalysis; iron catalysis

Domaines: Chimie organique; Catalyse

Jean Rodriguez, Adrien Quintard. Discovery of Eco-Compatible Synthetic Paths by a Multi-Catalysis Approach. CHIMIA, 2018, 72 (9), pp.580-583. ⟨10.2533/chimia.2018.580⟩. ⟨hal-01890347⟩