Fungal naphtho-γ-pyrones—secondary metabolites of industrial interest

Élodie Choque (1) , Youssef El Rayess (2) , José Raynal (1) , Florence Mathieu (1)

1 LGC - Laboratoire de Génie Chimique
2 USEK - Université Saint-Esprit de Kaslik

Naphtho-γ-pyrones (NGPs) are secondary metabolites mainly produced by filamentous fungi (Fusarium sp., Aspergillus sp.) that should be considered by industrials. Indeed, these natural biomolecules show various biological activities: anti-oxidant, anti-microbial, anti-cancer, anti-HIV, anti-hyperuricuric, anti-tubercular, or mammalian triacylglycerol synthesis inhibition which could be useful for pharmaceutical, cosmetic, and/or food industries. In this review, we draw an overview on the interest in studying fungal NGPs by presenting their biological activities and their potential values for industrials, their biochemical properties, and what is currently known on their biosynthetic pathway. Finally, we will present what remains to be discovered about NGPs.

Mots clés: Naphtho-γ-pyrones; Filamentous fungi; Aurasperone; Rubrofusarin; Anti-oxidant

Domaines: Génie chimique; Génie des procédés

Élodie Choque, Youssef El Rayess, José Raynal, Florence Mathieu. Fungal naphtho-γ-pyrones—secondary metabolites of industrial interest. Applied Microbiology and Biotechnology, 2015, 99 (3), pp.1081-1096. ⟨10.1007/s00253-014-6295-1⟩. ⟨hal-01888734⟩