[Other therapeutic strategies].

Dépression résistante : les autres stratégies thérapeutiques

Ghassen Saba (1, 2) , Isabel Nieto (2, 3) , Rémy Bation (2, 4) , Najib Allaïli (2, 3) , Djamila Bennabi (2, 5) , Fanny Moliere (2, 6) , Raphaëlle Richieri (2, 7) , Jérôme Holtzmann (2, 8) , Maxime Bubrovszky (2, 9) , Vincent Camus (2, 10) , Thomas Charpeaud (2, 11) , Philippe Courtet (2, 6, 12) , Pierre Courvoisier (2, 8) , Frédéric Haesebaert (2, 4) , Olivier Doumy (2, 13) , Wissam El-Hage (2, 10) , Marion Garnier (2, 11) , Thierry d'Amato (2, 4) , Thierry Bougerol (2, 8) , Christophe Lançon (2, 7) , Emmanuel Haffen (2, 5) , Pierre-Michel Llorca (2, 11) , Guillaume Vaiva (2, 9) , Frank Bellivier (2, 3) , Marion Leboyer (2, 1) , Bruno Aouizerate (2, 13)

1 Pôle de Psychiatrie [Hôpital Henri Mondor]
2 Fondation FondaMental [Créteil]
3 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
4 Centre Hospitalier le Vinatier [Bron]
5 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
6 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
7 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
8 Pôle Psychiatrie et Neurologie [Grenoble]
9 Service de Psychiatrie [CHRU Lille]
10 Clinique Psychiatrique Universitaire [Tours]
11 CHU Clermont-Ferrand
12 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
13 Centre hospitalier Charles Perrens [Bordeaux]

Non-selective and irreversible MAOI have become as third or fourth-line strategy for the management of treatment-resistant depression. Non-selective and irreversible MAOI requires careful monitoring of drug interactions and dietary restrictions. Nutritional supplements such as omega-3 have been found to produce beneficial effects in the management of treatment-resistant depression when administered in combination with the ongoing antidepressant treatment. The glutamate antagonist ketamine has been found to produce beneficial effects in the management of treatment-resistant depression while administered alone. Dopamine and/or norepinephrine agonists, such as methylphenidate, modafinil or pramipexole, have been found to produce beneficial effects in the management of treatment-resistant depression when administered in combination with the ongoing antidepressant treatment.

Domaines: Médecine humaine et pathologie

Ghassen Saba, Isabel Nieto, Rémy Bation, Najib Allaïli, Djamila Bennabi, et al.. Dépression résistante : les autres stratégies thérapeutiques. La Presse Médicale, 2016, 45 (3), pp.350 - 359. ⟨10.1016/j.lpm.2016.02.005⟩. ⟨hal-01872719⟩