Synthesis and in vitro characterization of trans- and cis-[18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor

Radouane Koudih (1, 2) , Gwénaëlle Gilbert (1, 2) , Martine Dhilly (2, 1) , Ahmed Abbas (1, 2) , Louisa Barre (1, 2) , Danièle Debruyne (1, 2) , Franck Sobrio (2, 1)

1 LDM-TEP - Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons
2 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales

Domaines: Sciences du Vivant [q-bio]; Radiochimie

Radouane Koudih, Gwénaëlle Gilbert, Martine Dhilly, Ahmed Abbas, Louisa Barre, et al.. Synthesis and in vitro characterization of trans- and cis-[18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor. European Journal of Medicinal Chemistry, 2012, 53, pp.408 - 415. ⟨10.1016/j.ejmech.2012.04.011⟩. ⟨hal-01853609⟩