Organo- and Copper-Multi-Catalyzed Pseudo Four-Component Access to gem -Difluorohydrins

Angela Ricucci (1) , Jean Rodriguez (1) , Adrien Quintard (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

A new efficient multi-catalytic pseudo four-component strategy combining an aldehyde, a-keto-acid and two equivalents of a fluorinating agent has been designed. Thanks to the combined effects of a secondary amine as organocatalyst

Mots clés: Fluorinated compounds; Fluorine; Organocatalysis; Copper catalysis; Multi-component

Domaines: Chimie organique

Angela Ricucci, Jean Rodriguez, Adrien Quintard. Organo- and Copper-Multi-Catalyzed Pseudo Four-Component Access to gem -Difluorohydrins. European Journal of Organic Chemistry, 2018, 2018 (27-28), pp.3697 - 3700. ⟨10.1002/ejoc.201701459⟩. ⟨hal-01850449⟩