Exploring the Robustness of the Parsimonious Reconciliation Method in Host-Symbiont Cophylogeny

Abstract : The aim of this paper is to explore the robustness of the parsimonious host-symbiont tree reconciliation method under editing or small perturbations of the input. The editing involves making different choices of unique symbiont mapping to a host in the case where multiple associations exist. This is made necessary by the fact that the tree reconciliation model is currently unable to handle such associations. The analysis performed could however also address the problem of errors. The perturbations are re-rootings of the symbiont tree to deal with a possibly wrong placement of the root specially in the case of fast-evolving species. In order to do this robustness analysis, we introduce a simulation scheme specifically designed for the host-symbiont cophylogeny context, as well as a measure to compare sets of tree reconciliations, both of which are of interest by themselves.
Type de document :
Article dans une revue
IEEE/ACM Transactions on Computational Biology and Bioinformatics, Institute of Electrical and Electronics Engineers, 2018, pp.1-11. 〈10.1109/TCBB.2018.2838667〉
Liste complète des métadonnées

Littérature citée [40 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01842451
Contributeur : Marie-France Sagot <>
Soumis le : mercredi 18 juillet 2018 - 12:13:42
Dernière modification le : samedi 16 mars 2019 - 01:30:11
Document(s) archivé(s) le : vendredi 19 octobre 2018 - 19:19:59

Fichier

Robustness_Cophylogeny.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Laura Urbini, Blerina Sinaimeri, Catherine Matias, Marie-France Sagot. Exploring the Robustness of the Parsimonious Reconciliation Method in Host-Symbiont Cophylogeny. IEEE/ACM Transactions on Computational Biology and Bioinformatics, Institute of Electrical and Electronics Engineers, 2018, pp.1-11. 〈10.1109/TCBB.2018.2838667〉. 〈hal-01842451〉

Partager

Métriques

Consultations de la notice

323

Téléchargements de fichiers

81