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, Investments for the Future' ProgrammeReference Agence Nationale de la Recherche (ANR)-10- IDEX-03-02) The technical support of Lionel Buisson at the Centre de Recherche Paul Pascal (Pessac, F) is warmly acknowledged also acknowledge fruitful discussions with Nicolas Bremond and Jean Baudry (ESPCI, Paris; F) for the assembly of 2D incubation chambers and with Yves Gibon (INRA, Villenave d'Ornon; F) for the enzymology of the systems, ERC Grant agreement 306385?SofI); D) for his critical comments and inputs on the manuscript

T. B. Author, performed research on microfluidics and integration of IMVs in droplets and contributed to the design of the research under the supervision of performed research on IMVs preparation under the supervision of I.I. and T

C. W. and J. B. , performed the numerical simulations analyzed data and wrote the paper with contributions of all authors