Na(+) channel function, regulation, structure, trafficking and sequestration

Ye Chen-Izu , Robin M. Shaw , Geoffrey S. Pitt , Vladimir Yarov-Yarovoy (1) , Jon T. Sack , Hugues Abriel (2, 3) , Richard W. Aldrich , Luiz Belardinelli , Mark B. Cannell , William A. Catterall , Walter J. Chazin (4) , Nipavan Chiamvimonvat , Isabelle Deschenes (5) , Eleonora Grandi , Thomas J. Hund , Leighton T. Izu , Lars S. Maier , Victor A. Maltsev , Celine Marionneau (6) , Peter J. Mohler , Sridharan Rajamani , Randall L. Rasmusson , Eric A. Sobie , Colleen E. Clancy , Donald M. Bers

1 Department of Pharmacology
2 Department of Pharmacology and Toxicology
3 Service of Cardiology
4 Departments of biochemistry and chemistry [Nashville]
5 MetroHealth Medical Center
6 ITX - ITX - unité de recherche de l'institut du thorax

This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na(+) channel and Na(+) transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na(+) channel function and regulation, Na(+) channel structure and function, and Na(+) channel trafficking, sequestration and complexing.

Mots clés: Abbreviations AP; action potential; CaM; calmodulin; CaMKII; CaM-dependent protein kinase II; Cx43; connexin43; EAD; early afterdepolarization; E m; membrane potential; I Na; Na + current; I NaL; the late Na + current; LQT3; long QT syndrome type 3; Na V channel; voltage-gated sodium channel; PD; pore-forming domain; VSD; voltage-sensing domain

Domaines: Sciences du Vivant [q-bio]

Ye Chen-Izu, Robin M. Shaw, Geoffrey S. Pitt, Vladimir Yarov-Yarovoy, Jon T. Sack, et al.. Na(+) channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology, 2015, Equipe 1, 593 (6), pp.1347--1360. ⟨10.1113/jphysiol.2014.281428⟩. ⟨hal-01830588⟩