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Attenuation correction synthesis for hybrid PET-MR scanners: Application to brain studies

Abstract : Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient's morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.
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https://hal.inria.fr/hal-01827217
Contributor : Ninon Burgos <>
Submitted on : Sunday, July 1, 2018 - 10:43:02 PM
Last modification on : Saturday, October 6, 2018 - 7:24:01 PM

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Ninon Burgos, M. J. Cardoso, K. Thielemans, M. Modat, S. Pedemonte, et al.. Attenuation correction synthesis for hybrid PET-MR scanners: Application to brain studies. IEEE Transactions on Medical Imaging, Institute of Electrical and Electronics Engineers, 2014, 33 (12), pp.2332--2341. ⟨10.1109/TMI.2014.2340135⟩. ⟨hal-01827217⟩

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