Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis

Dimitri Renard (1) , Audrey Gabelle (2, 3) , Christophe Hirtz (2) , Christophe Demattei (4) , Eric Thouvenot (1, 5) , Sylvain Lehmann (2)

1 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
2 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
3 CMRR - Centres Mémoire de Ressources et de Recherche Montpellier
4 BESPIM
5 IGF - Institut de Génomique Fonctionnelle

We evaluated cerebrospinal fluid amyloid-β 1-40 (Aβ40), amyloid-β 1-42 (Aβ42), total and phosphorylated-tau (t-tau and p-tau) in patients with symptomatic isolated cortical supratentorial superficial siderosis (SS), by prospectively recruiting ten patients with SS in the absence of pre-existing cognitive dysfunction, and comparing biomarkers with lobar hematoma cerebral amyloid angiopathy patients (LH-CAA, n = 13), Alzheimer's disease patients (AD, n = 42), and controls (n = 16). Compared to controls, SS patients showed statistically significant higher t-tau (p = 0.019) and lower Aβ42 (p = 0.0084). Compared to other groups, SS showed statistically significant lower t-tau, p-tau, and Aβ40 compared to AD (p = 0.0063, p = 0.0004, and p = 0022, respectively), and higher p-tau compared to LH-CAA (p = 0.012).

Mots clés: Amyloid-β; cerebral amyloid angiopathy; cerebrospinal fluid; superficial siderosis; tau

Domaines: Neurosciences [q-bio.NC]

Dimitri Renard, Audrey Gabelle, Christophe Hirtz, Christophe Demattei, Eric Thouvenot, et al.. Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis. Journal of Alzheimer's Disease, 2016, 54 (4), pp.1291 - 1295. ⟨10.3233/JAD-160400⟩. ⟨hal-01825499⟩