Glutathione: Antioxidant Properties Dedicated to Nanotechnologies

Caroline Gaucher (1) , Ariane Boudier (1) , Justine Bonetti (1) , Igor Clarot (1) , Pierre Leroy (1) , Marianne Parent (1)

1 CITHEFOR - Cibles thérapeutiques, formulation et expertise pré-clinique du médicament

Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in GSH should not be restricted to its redox properties. This multidisciplinary review aims to bring out some lesser-known aspects of GSH, for example, as an emerging tool in nanotechnologies to achieve targeted drug delivery. After recalling the biochemistry of GSH, including its metabolism pathways and redox properties, its involvement in cellular redox homeostasis and signaling is described. Analytical methods for the dosage and localization of GSH or glutathiolated proteins are also covered. Finally, the various therapeutic strategies to replenish GSH stocks are discussed, in parallel with its use as an addressing molecule in drug delivery.

Mots clés: nanotechnologies; targeted drug delivery; repletion; glutathione; antioxidant; redox signaling

Domaines: Sciences pharmaceutiques

Caroline Gaucher, Ariane Boudier, Justine Bonetti, Igor Clarot, Pierre Leroy, et al.. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants , 2018, 7 (5), pp.62. ⟨10.3390/antiox7050062⟩. ⟨hal-01823460⟩