P. Chanez, Severe asthma is an epithelial disease, European Respiratory Journal, vol.25, issue.6, pp.945-946, 2005.
DOI : 10.1183/09031936.05.00038605

P. Camner, B. Mossberg, and K. Philipson, Tracheobronchial clearance and chronic obstructive lung disease, Scandinavian journal of respiratory diseases, vol.54, issue.5, pp.272-281, 1973.

B. Button, A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia, Science, vol.122, issue.1, pp.937-9411223012, 2012.
DOI : 10.1063/1.1829255

M. Sanderson and M. Sleigh, Ciliary activity of cultured rabbit tracheal epithelium: beat pattern and metachrony, Journal of Cell Science, vol.47, pp.331-347, 1981.

M. R. Knowles and R. C. Boucher, Mucus clearance as a primary innate defense mechanism for mammalian airways, Journal of Clinical Investigation, vol.109, issue.5, p.571, 2002.
DOI : 10.1172/JCI0215217

S. K. Lai, Y. Wang, D. Wirtz, and J. Hanes, Micro-and macrorheology of mucus. Advanced drug delivery reviews 61, pp.86-100, 2009.

E. K. Vladar, Y. L. Lee, T. Stearns, and J. D. Axelrod, Observing planar cell polarity in multiciliated mouse airway epithelial cells, Methods in cell biology, vol.127, pp.37-54, 2015.
DOI : 10.1016/bs.mcb.2015.01.016

P. R. Sears, W. Yin, and L. Ostrowski, Continuous mucociliary transport by primary human airway epithelial cells in vitro, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.272, issue.2, pp.99-108, 2015.
DOI : 10.1371/journal.pbio.1000155

R. Faubel, C. Westendorf, E. Bodenschatz, and G. Eichele, Cilia-based flow network in the brain ventricles, Science, vol.53, issue.4, pp.176-178, 2016.
DOI : 10.1016/j.ymeth.2010.12.020

W. D. Bennett, Multisite Comparison of Mucociliary and Cough Clearance Measures Using Standardized Methods, Journal of Aerosol Medicine and Pulmonary Drug Delivery, vol.26, issue.3, pp.157-164, 2013.
DOI : 10.1089/jamp.2011.0909

W. M. Foster, D. M. Walters, M. Longphre, K. Macri, and L. M. Miller, Methodology for the measurement of mucociliary function in the mouse by scintigraphy, Journal of Applied Physiology, vol.273, issue.3, pp.1111-1118, 2001.
DOI : 10.1152/ajpcell.1997.272.3.C853

J. C. Lay, M. R. Stang, P. E. Fisher, J. R. Yankaskas, and W. Bennett, Airway Retention of Materials of Different Solubility following Local Intrabronchial Deposition in Dogs, Journal of Aerosol Medicine, vol.16, issue.2, pp.153-166, 2003.
DOI : 10.1089/089426803321919915

A. R. Bhashyam, A Pilot Study to Examine the Effect of Chronic Treatment with Immunosuppressive Drugs on Mucociliary Clearance in a Vagotomized Murine Model, PLoS ONE, vol.7, issue.9, p.45312, 2012.
DOI : 10.1371/journal.pone.0045312.g004

M. J. Hoegger, Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs, Proceedings of the National Academy of Sciences, vol.111, issue.6, pp.2355-2360, 2014.
DOI : 10.1139/y95-025

M. Donnelley, High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging, Respiratory Research, vol.21, issue.Suppl 2, p.95, 2017.
DOI : 10.1107/S160057751400856X

, SCIeNtIFIC REPORTS |, vol.8, 2018.

T. E. Gray, K. Guzman, C. W. Davis, L. H. Abdullah, and P. Nettesheim, Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells., American Journal of Respiratory Cell and Molecular Biology, vol.14, issue.1, pp.104-112, 1996.
DOI : 10.1165/ajrcmb.14.1.8534481

D. Gras, An ex??vivo model of severe asthma using reconstituted human bronchial epithelium, Journal of Allergy and Clinical Immunology, vol.129, issue.5, pp.1259-1266, 2012.
DOI : 10.1016/j.jaci.2012.01.073

H. Matsui, Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease, Cell, vol.95, issue.7, pp.1005-1015, 1998.
DOI : 10.1016/S0092-8674(00)81724-9

R. Tarran, Normal and Cystic Fibrosis Airway Surface Liquid Homeostasis, Journal of Biological Chemistry, vol.9, issue.42, pp.35751-35759, 2005.
DOI : 10.1007/BF01797773

L. Zhang, CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium, PLoS Biology, vol.211, issue.7, p.1000155, 2009.
DOI : 10.1371/journal.pbio.1000155.s005

B. Button, R. C. Boucher, C. Of-north, and U. Virtual-lung-group, Role of mechanical stress in regulating airway surface hydration and mucus clearance rates, Respiratory Physiology & Neurobiology, vol.163, issue.1-3, pp.189-201, 2008.
DOI : 10.1016/j.resp.2008.04.020

B. Thomas, Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma, Journal of Allergy and Clinical Immunology, vol.126, issue.4, pp.722-729, 2010.
DOI : 10.1016/j.jaci.2010.05.046

M. M. Chang, L. Shih, and R. Wu, Pulmonary epithelium: cell types and functions. The Pulmonary Epithelium in Health and Disease, pp.2-26, 2008.
DOI : 10.1002/9780470727010.ch1

URL : http://media.wiley.com/product_data/excerpt/16/04700595/0470059516.pdf

J. C. Parker, IL-31 does not induce normal human ciliated epithelial cells to differentiate into a phenotype consistent with the pathophysiology of asthma, Results in Immunology, vol.2, pp.104-111, 2012.
DOI : 10.1016/j.rinim.2012.05.001

D. Adam, Cystic fibrosis airway epithelium remodelling: involvement of inflammation, The Journal of Pathology, vol.14, issue.3, pp.408-419, 2015.
DOI : 10.1186/1465-9921-14-38

T. Raman, Quality control in microarray assessment of gene expression in human airway epithelium, BMC Genomics, vol.10, issue.1, p.493, 2009.
DOI : 10.1186/1471-2164-10-493

M. King, A. Gilboa, F. Meyer, and A. Silberberg, On the transport of mucus and its rheologic simulants in ciliated systems 1, 2, American Review of Respiratory Disease, vol.110, pp.740-745, 1974.

W. Hofmann and B. Asgharian, The Effect of Lung Structure on Mucociliary Clearance and Particle Retention in Human and Rat Lungs, Toxicological Sciences, vol.73, issue.2, pp.448-456, 2003.
DOI : 10.1093/toxsci/kfg075

D. Lafkas, Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung, Nature, vol.945, p.127, 2015.
DOI : 10.1371/journal.pone.0070221

R. J. Francis, Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.296, issue.6, pp.1067-1075, 2009.
DOI : 10.1165/rcmb.2006-0475RC

M. C. Marchetti, Hydrodynamics of soft active matter, Reviews of Modern Physics, vol.109, issue.3, p.1143, 2013.
DOI : 10.1140/epje/i2005-10029-3

S. Ramaswamy, The Mechanics and Statistics of Active Matter, Annual Review of Condensed Matter Physics, vol.1, issue.1, pp.323-345, 2010.
DOI : 10.1146/annurev-conmatphys-070909-104101

URL : http://arxiv.org/pdf/1004.1933

I. Vachier, Glucocorticoid receptors in bronchial epithelial cells in asthma American journal of respiratory and critical care medicine 158, pp.963-970, 1998.

Z. Püspöki, M. Storath, D. Sage, and M. Unser, Transforms and operators for directional bioimage analysis: a survey, Focus on Bio- Image Informatics, pp.69-93, 2016.

M. R. Staudt, Smoking is associated with a loss of ciliated cells throughout the airways, C26. TOBACCO: HOW IT HARMS US AND MORE REASONS TO QUIT, pp.4097-4097, 2014.