Skip to Main content Skip to Navigation
Journal articles

Mechanically induced development and maturation of human intestinal organoids in vivo

Abstract : The natural ability of stem cells to self-organize into functional tissue has been harnessed for the production of functional human intestinal organoids. Although dynamic mechanical forces play a Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms * Correspondence and requests for materials should be addressed to Maxime M. Mahe: maxime.mahe@cchmc.org. + previous affiliation Author Contributions H.M.P. and M.M.M. conceived and designed the study; H.M.P., D.W., T.A.H., M.A.H., and M.M.M. performed experiments and collected data; N.B. generated HIOs; N. H. and J.C.Y.D. manufactured springs; H.M.P., D.W., S.C., and M.M.M. analyzed data; H.M.P., M.B., S.P.H., J.M.W., M.A.H., and M.M.M. interpreted experimental findings; H.M.P. and M.M.M. prepared figures and drafted manuscript; H.M.P., S.P.H., J.M.W., M.A.H., and M.M.M. made critical revisions to the manuscript; all authors approved the manuscript's final version.
Complete list of metadatas

Cited literature [51 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01816387
Contributor : Samuel Chaffron <>
Submitted on : Thursday, April 9, 2020 - 10:23:26 AM
Last modification on : Tuesday, April 14, 2020 - 3:46:10 PM

File

nihms963497.pdf
Files produced by the author(s)

Identifiers

Citation

Holly Poling, David Wu, Nicole Brown, Michael Baker, Taylor Hausfeld, et al.. Mechanically induced development and maturation of human intestinal organoids in vivo. Nature Biomedical Engineering, Nature Publishing Group, 2018, 2 (6), pp.429 - 442. ⟨10.1038/s41551-018-0243-9⟩. ⟨hal-01816387⟩

Share

Metrics

Record views

203

Files downloads

24