Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

Florian A Britto (1) , Fabienne Cortade (1) , Yassine Belloum (1) , Marine Blaquière (2) , Yann Gallot (3) , Aurélie Docquier (1) , Allan Pagano (1) , Elodie Jublanc (1) , Nadia Bendridi (4) , Christelle Koechlin-Ramonatxo (1) , Béatrice Chabi (1) , Marc Francaux (5) , François Casas (1) , Damien Freyssenet (3) , Jennifer Rieusset (4) , Sophie Giorgetti-Peraldi (6) , Gilles Carnac (2) , Vincent Ollendorff (1) , François Bertrand Favier (1)

1 DMEM - Dynamique Musculaire et Métabolisme
2 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
3 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
4 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
5 UCL - Université Catholique de Louvain = Catholic University of Louvain
6 COMUE UCA - COMUE Université Côte d'Azur (2015-2019)

Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through inhibition of the Akt/mTORC1 signaling pathway. REDD1 expression is notably induced following glucocorticoid secretion, which is a component of energy stress responses.

Mots clés: mTOR; Mitochondria; Energy expenditure; Exercise; Skeletal muscle; Metabolism; MAMs; Hypoxia; Fasting

Domaines: Sciences du Vivant [q-bio]

Florian A Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann Gallot, et al.. Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. BMC Biology, 2018, 16 (1), pp.65. ⟨10.1186/s12915-018-0525-4⟩. ⟨hal-01815521⟩