Radiolabeled dendritic probes as tools for high in vivo tumor targeting: application to melanoma

Abstract : In bioimaging, targeting allows refining the diagnosis by improving the sensitivity and especially the specificity for an earlier diagnosis. Two 111In-radiolabeled dendritic nanoprobes (DPs) (In-111-2, In-111-3) and their model counterparts (In-111-1, In-111-4) are designed and assessed for in vitro and in vivo tumor targeting efficiency in a murine melanoma models. Tumor uptake is correlated to dendrimer multivalency and reaches values as high as 12.7 +/- 1.6% ID g(-1) at 4 h post intravenous injection for In-111-3 vs. 1.5 +/- 0.5% ID g(-1) for the unfunctionalized DP, and over 11% ID g(-1) for any tumor weight whatsoever.
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https://hal.archives-ouvertes.fr/hal-01814287
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Submitted on : Wednesday, June 13, 2018 - 10:38:00 AM
Last modification on : Friday, April 12, 2019 - 1:33:13 AM

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Audrey Parat, David Kryza, Francoise Degoul, Jacqueline Taleb, Claire Viallard, et al.. Radiolabeled dendritic probes as tools for high in vivo tumor targeting: application to melanoma. Journal of materials chemistry‎ B, Royal Society of Chemistry, 2015, 3 (12), pp.2560-2571. ⟨10.1039/c5tb00235d⟩. ⟨hal-01814287⟩

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