Solubility of a pharmaceutical solid in supercritical mixtures : measurements and modelling

Martial Sauceau (1) , Jean‐jacques Letourneau (1) , Dominique Richon (2) , Jacques Fages (1)

1 Poudres et procédés - Ecole des Mines Albi-Carmaux
2 École des Mines de Paris

The solubility in supercritical fluids of a solid of pharmaceutical interest has been investigated by means of an orifginal apparatus. Solubility values of this solid in supercritical pure CO2 in the pressure range of 8-30 MPa are reported along the isotherms 308.15 and 318.15 K. The data are then correlated using the Chrastil model, an empirical density-based model. The effect of a co-solvent, ethanol, has been examined under supercritical solutions as well.

Domaines: Génie des procédés; Sciences de l'ingénieur [physics]; Pharmacie galénique

Martial Sauceau, Jean‐jacques Letourneau, Dominique Richon, Jacques Fages. Solubility of a pharmaceutical solid in supercritical mixtures : measurements and modelling. 7th Meeting on supercritical fluids: Particle Design - Materials and Natural Products Processing, ISASF International Society for the Advancement of Supercritical Fluids, Dec 2000, Antibes-Juan les Pins, France. p.959-964. ⟨hal-01808920⟩