Design, synthesis and evaluation of progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux

Wael Zeinyeh (1) , Ghina Alameh , Sylvie Radix (2) , Catherine Grenot , Charles Dumontet (3) , Nadia Walchshofer (2)

1 CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant
2 B2C - Biomolécules Cancer et Chimiorésistances
3 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon

Domaines: Chimie thérapeutique; Chimie organique

Wael Zeinyeh, Ghina Alameh, Sylvie Radix, Catherine Grenot, Charles Dumontet, et al.. Design, synthesis and evaluation of progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux. Bioorganic and Medicinal Chemistry Letters, 2010, 20 (10), pp.3165 - 3168. ⟨10.1016/j.bmcl.2010.03.085⟩. ⟨hal-01800193⟩