Cellular and functional mechanisms underlying muscle aging and associated diseases

Marine Gueugneau (1) , Cécile Coudy-Gandilhon (1) , Frédéic Roche (2, 3) , Jean-Claude Barthélémy (2, 3) , Léonard Féasson (4, 5, 3, 6) , Daniel Béchet (1)

1 UNH - Unité de Nutrition Humaine
2 Service de Physiologie Clinique et de l'Exercice [CHU de Saint-Etienne]
3 UJM - Université Jean Monnet - Saint-Étienne
4 Unité de Myologie
5 LPE - Laboratoire de Physiologie de l'Exercice
6 Université de Lyon

The loss of skeletal muscle mass and function during the aging process (sarcopenia) has a major impact on muscle function and is a key component of frailty. A clear understanding of the mechanisms of sarcopenia through the identification of selective biomarkers, and thus of potential therapeutic targets, is of paramount importance in ensuring quality of life in old age. This presentation will provide an overview of the studies associating immunohistology and omics investigations during sarcopenia and associated pathologies in humans.

Domaines: Santé publique et épidémiologie; Alimentation et Nutrition

Marine Gueugneau, Cécile Coudy-Gandilhon, Frédéic Roche, Jean-Claude Barthélémy, Léonard Féasson, et al.. Cellular and functional mechanisms underlying muscle aging and associated diseases. Nestle Purina Companion Animal Nutrition (CAN) Summit 2018, May 2018, Charleston, South Carolina, United States. ⟨hal-01799543⟩