Characterization of homologous 5- hydroxytryptamine4 receptor desensitization in colliculi neurons, Mol Pharmacol, vol.42, pp.808-816, 1992. ,
Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology, Journal of Neuroscience, vol.32, issue.30, pp.10201-10210, 2012. ,
DOI : 10.1523/JNEUROSCI.1496-12.2012
MT5-MMP Promotes Alzheimer???s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro, Frontiers in Molecular Neuroscience, vol.90, issue.163, 2016. ,
DOI : 10.1016/j.neuron.2016.05.003
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer???s disease, Cellular and Molecular Life Sciences, vol.8, issue.10, pp.217-236, 2016. ,
DOI : 10.1038/nn1531
Endogenous and synthetic MMP inhibitors in CNS physiopathology, Prog Brain Res, vol.214, pp.313-351, 2014. ,
DOI : 10.1016/B978-0-444-63486-3.00014-1
URL : https://hal.archives-ouvertes.fr/hal-01718187
Elusive roles for reactive astrocytes in neurodegenerative diseases, Front Cell Neurosci, vol.9, p.278, 2015. ,
(4) receptors, a place in the sun: act two, Curr Opin Pharmacol, vol.11, pp.5-87, 2011. ,
DOI : 10.1016/j.coph.2011.01.012
URL : https://hal.archives-ouvertes.fr/hal-01667589
Neuropathological stageing of Alzheimer-related changes, Acta Neuropathologica, vol.80, issue.4, pp.239-259, 1991. ,
DOI : 10.1007/978-3-642-70644-8_2
Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice, Behavioural Brain Research, vol.187, issue.2, pp.455-461, 2008. ,
DOI : 10.1016/j.bbr.2007.10.008
Selective impairment of subcategories of long-term memory in mice with hippocampal lesions accessed by the olfactory tubing maze, Behavioural Brain Research, vol.158, issue.2, pp.285-292, 2005. ,
DOI : 10.1016/j.bbr.2004.09.008
URL : https://hal.archives-ouvertes.fr/hal-00095168
Gender and incidence of dementia in the Framingham Heart Study from mid-adult life, Alzheimer's & Dementia, vol.11, issue.3, pp.310-320, 2015. ,
DOI : 10.1016/j.jalz.2013.10.005
URL : https://hal.archives-ouvertes.fr/inserm-00936580
Activation of 5-HT4 receptors inhibits secretion of ??-amyloid peptides and increases neuronal survival, Experimental Neurology, vol.203, issue.1, pp.274-278, 2007. ,
DOI : 10.1016/j.expneurol.2006.07.021
Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10, ACS Chemical Neuroscience, vol.4, issue.1, pp.130-140 ,
DOI : 10.1021/cn300095t
URL : http://europepmc.org/articles/pmc3547471?pdf=render
5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex, NeuroReport, vol.5, issue.10, pp.1230-1232, 1994. ,
DOI : 10.1097/00001756-199406020-00018
Area-Specific Alterations of Synaptic Plasticity in the 5XFAD Mouse Model of Alzheimer???s Disease: Dissociation between Somatosensory Cortex and Hippocampus, PLoS ONE, vol.27, issue.9, p.74667, 2013. ,
DOI : 10.1371/journal.pone.0074667.g003
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process, Physiological Reviews, vol.5, issue.2, pp.465-494, 2010. ,
DOI : 10.1523/JNEUROSCI.1549-07.2007
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease, Journal of Neurology, Neurosurgery & Psychiatry, vol.71, issue.4, pp.441-447, 2001. ,
DOI : 10.1136/jnnp.71.4.441
Cardiovascular risk profile in women and dementia, J Alzheimers Dis, vol.42, pp.353-363, 2014. ,
Viral gene transfer of APPs?? rescues synaptic failure in an Alzheimer???s disease mouse model, Acta Neuropathologica, vol.29, issue.2, pp.247-266, 2016. ,
DOI : 10.1523/JNEUROSCI.4104-09.2009
The Effects of Novel, Selective 5-Hydroxytryptamine (5-HT) 4 Receptor Ligands in Rat Spatial Navigation, Neuropharmacology, vol.36, issue.4-5, pp.689-696, 1997. ,
DOI : 10.1016/S0028-3908(97)00055-5
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice, Behavioural Brain Research, vol.230, issue.1, pp.304-308, 2012. ,
DOI : 10.1016/j.bbr.2012.02.012
URL : https://hal.archives-ouvertes.fr/hal-00862757
Calcium channel blockade attenuates abnormal synaptic transmission in the dentate gyrus elicited by entorhinal amyloidopathy, Synapse, vol.25, issue.10, pp.408-417, 2016. ,
DOI : 10.1523/JNEUROSCI.4554-04.2005
Neural substrates of spatial and temporal disorientation in Alzheimer's disease, Acta Neuropathologica, vol.100, issue.2, pp.189-195, 2000. ,
DOI : 10.1007/s004019900166
Cerebrovascular pathology during the progression of experimental Alzheimer's disease, Neurobiology of Disease, vol.88, pp.107-117, 2016. ,
DOI : 10.1016/j.nbd.2016.01.001
Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer???s disease, Frontiers in Aging Neuroscience, vol.5, p.96, 2013. ,
DOI : 10.3389/fnagi.2013.00096
URL : https://hal.archives-ouvertes.fr/hal-01703910
The FVB/N mice: A well suited strain to study learning and memory processes using olfactory cues, Behavioural Brain Research, vol.296, pp.254-259, 2016. ,
DOI : 10.1016/j.bbr.2015.09.004
URL : https://hal.archives-ouvertes.fr/hal-01477821
Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease, Hippocampus, vol.29, issue.7, pp.762-772, 2014. ,
DOI : 10.1016/j.neurobiolaging.2006.12.004
receptor levels in hippocampus correlates inversely with memory test performance in humans, Human Brain Mapping, vol.73, issue.1-2, pp.3066-3074, 2013. ,
DOI : 10.1016/0166-4328(96)00108-8
Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer???s disease, Acta Neuropathologica, vol.8, issue.7, pp.565-583, 2015. ,
DOI : 10.1186/1742-2094-8-150
5-HT4 Receptor Stimulation Leads to Soluble A??PP?? Production Through MMP-9 Upregulation, Journal of Alzheimer's Disease, vol.32, issue.2, pp.437-445, 2012. ,
DOI : 10.3233/JAD-2012-111235
Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer???s Disease: A Translational Overview, Current Pharmaceutical Design, vol.21, issue.3, pp.317-331, 2015. ,
DOI : 10.2174/1381612820666140826114601
Neuroinflammation in Alzheimer's disease, The Lancet Neurology, vol.14, issue.4, pp.388-405, 2015. ,
DOI : 10.1016/S1474-4422(15)70016-5
Deficits of the cholinergic system in early AD, Neuropsychologia, vol.46, issue.6, pp.1642-1647, 2008. ,
DOI : 10.1016/j.neuropsychologia.2007.11.024
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model, Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model, pp.92-103, 2008. ,
DOI : 10.1016/j.brainres.2008.03.079
Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications, Neuropsychologia, vol.33, issue.4, pp.441-459, 1995. ,
DOI : 10.1016/0028-3932(94)00127-B
The 5-Hydroxytryptamine4 Receptor Agonists Prucalopride and PRX-03140 Increase Acetylcholine and Histamine Levels in the Rat Prefrontal Cortex and the Power of Stimulated Hippocampal ?? Oscillations, Journal of Pharmacology and Experimental Therapeutics, vol.341, issue.3, pp.681-691, 2012. ,
DOI : 10.1124/jpet.112.192351
Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory, 2005. ,
DOI : 10.1111/j.1460-9568.2005.04426.x
URL : https://hal.archives-ouvertes.fr/hal-00095130
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease, Nature Neuroscience, vol.1496, issue.2, pp.304-311, 2014. ,
DOI : 10.1016/j.neurobiolaging.2006.03.007
URL : http://europepmc.org/articles/pmc4044925?pdf=render
Vasoactive Intestinal Peptide and Pituitary Adenylyl Cyclase-Activating Polypeptide Inhibit Tumor Necrosis Factor-?? Production in Injured Spinal Cord and in Activated Microglia via a cAMP-Dependent Pathway, The Journal of Neuroscience, vol.20, issue.10, pp.3622-3630, 2000. ,
DOI : 10.1523/JNEUROSCI.20-10-03622.2000
Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal ??-Catenin Pathway Function in an Alzheimer's Disease Model, The Journal of Immunology, vol.187, issue.12, pp.6539-6549, 2011. ,
DOI : 10.4049/jimmunol.1100620
URL : http://www.jimmunol.org/content/jimmunol/187/12/6539.full.pdf
ADAM10 is the physiologically relevant, constitutive ??-secretase of the amyloid precursor protein in primary neurons, The EMBO Journal, vol.16, issue.17, pp.3020-3032, 2010. ,
DOI : 10.1126/science.1132341
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment, Proceedings of the National Academy of Sciences, vol.7, issue.5, pp.3825-3830, 2014. ,
DOI : 10.1016/0006-2952(61)90145-9
5-HT 4 Receptors Improve Social Olfactory Memory in the Rat, Neuropharmacology, vol.36, issue.4-5, pp.681-687, 1997. ,
DOI : 10.1016/S0028-3908(96)00169-4
Microglia in Alzheimer???s Disease, BioMed Research International, vol.13, issue.3, p.437483, 2014. ,
DOI : 10.1016/j.brainresrev.2004.06.006
SSP-002392, a new 5-HT4 receptor agonist, dose-dependently reverses scopolamine-induced learning and memory impairments in C57Bl/6 mice, Neuropharmacology, vol.85, pp.178-189, 2014. ,
DOI : 10.1016/j.neuropharm.2014.05.013
C]SB207145 PET study, Journal of Cerebral Blood Flow & Metabolism, vol.32, issue.6, pp.1475-1481, 2011. ,
DOI : 10.1097/00004728-199207000-00024
Cerebral Serotonin 4 Receptors and Amyloid-?? in Early Alzheimer's Disease, Journal of Alzheimer's Disease, vol.26, issue.3, pp.457-466, 2011. ,
DOI : 10.3233/JAD-2011-110056
Crosstalk between Rap1 and Rac regulates secretion of sAPP??, Nature Cell Biology, vol.20, issue.7, pp.633-639, 2003. ,
DOI : 10.1016/0165-0270(87)90041-0
Modifications of 5-HT4 receptor expression in rat brain during memory consolidation, Brain Research, vol.1042, issue.1, pp.73-81, 2005. ,
DOI : 10.1016/j.brainres.2005.02.020
BIMU1 Increases Associative Memory in Rats by Activating 5-HT 4 Receptors, Neuropharmacology, vol.36, issue.4-5, pp.697-706, 1997. ,
DOI : 10.1016/S0028-3908(97)00058-0
Modulation of memory processes and cellular excitability in the dentate gyrus of freely moving rats by a 5-HT4 receptors partial agonist, and an antagonist, Neuropharmacology, vol.47, issue.7, pp.1021-1035, 2004. ,
DOI : 10.1016/j.neuropharm.2004.06.033
Differential modulation of the 5-HT4 receptor agonists and antagonist on rat learning and memory, Neuropharmacology, vol.39, issue.11, pp.2017-2027, 2000. ,
DOI : 10.1016/S0028-3908(00)00038-1
Enhancement of reference memory in aged rats by specific activation of 5-HT4 receptors using an olfactory associative discrimination task, Brain Research, vol.1405, pp.49-56, 2011. ,
DOI : 10.1016/j.brainres.2011.06.020
URL : https://hal.archives-ouvertes.fr/hal-01770092
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes, Acta Neuropathologica, vol.5, issue.4, pp.1-19, 2015. ,
DOI : 10.4161/cam.5.4.16986
URL : http://europepmc.org/articles/pmc4282969?pdf=render
Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation, Journal of Neuroscience, vol.26, issue.40, pp.10129-10140, 2006. ,
DOI : 10.1523/JNEUROSCI.1202-06.2006
URL : http://www.jneurosci.org/content/jneuro/26/40/10129.full.pdf
??-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease, Brain, vol.130, issue.11, pp.2837-2844, 2007. ,
DOI : 10.1093/brain/awm238
URL : https://academic.oup.com/brain/article-pdf/130/11/2837/948619/awm238.pdf
Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP, Front Aging Neurosci, vol.6, p.247, 2014. ,
Strain Differences in Rewarded Discrimination Learning Using the Olfactory Tubing Maze, Behavior Genetics, vol.128, issue.1, pp.923-934, 2006. ,
DOI : 10.2466/pr0.1971.29.1.195
The Promnesic Effect of G-protein-Coupled 5-HT4 Receptors Activation Is Mediated by a Potentiation of Learning-Induced Spine Growth in the Mouse Hippocampus, Neuropsychopharmacology, vol.77, issue.10, pp.2427-2434, 2008. ,
DOI : 10.1038/sj.npp.1301644
Simultaneous olfactory discrimination elicits a strain-specific increase in dendritic spines in the hippocampus of inbred mice, Hippocampus, vol.523, issue.5, pp.472-479, 2006. ,
DOI : 10.1002/hipo.20174
URL : https://hal.archives-ouvertes.fr/hal-00095116
5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases, British Journal of Pharmacology, vol.110, issue.Suppl 2, pp.993-998, 1995. ,
DOI : 10.1016/0028-3908(94)90084-1
R) Agonist Activities As Potential Agents against Alzheimer???s Disease: The Design of Donecopride, Journal of Medicinal Chemistry, vol.58, issue.7, pp.3172-3187, 2015. ,
DOI : 10.1021/acs.jmedchem.5b00115
Sex and Genotype Differences in Odor Detection in the 3??Tg-AD and 5XFAD Mouse Models of Alzheimer???s Disease at 6 Months of Age, Chemical Senses, vol.37, issue.4, pp.433-440, 2016. ,
DOI : 10.1016/j.bbr.2012.09.019
The olfactory tubing maze: a new apparatus for studying learning and memory processes in mice, Journal of Neuroscience Methods, vol.117, issue.2, pp.173-181, 2002. ,
DOI : 10.1016/S0165-0270(02)00094-8
URL : https://hal.archives-ouvertes.fr/hal-00095340
Brain Amyloid Imaging, Journal of Nuclear Medicine Technology, vol.41, issue.1, pp.11-18, 2013. ,
DOI : 10.2967/jnumed.110.076315
Soluble oligomers of the amyloid ??-protein impair synaptic plasticity and behavior, Behavioural Brain Research, vol.192, issue.1, pp.106-113, 2008. ,
DOI : 10.1016/j.bbr.2008.02.016
URL : http://europepmc.org/articles/pmc2601528?pdf=render
The amyloid hypothesis of Alzheimer's disease at 25??years, EMBO Molecular Medicine, vol.8, issue.6, pp.595-608, 2016. ,
DOI : 10.15252/emmm.201606210
Neuroprotection by cAMP, Adv Exp Med Biol, vol.557, pp.164-176, 2006. ,
DOI : 10.1007/0-387-30128-3_10
The Cognitive Neuroscience of Human Memory Since H.M., Annual Review of Neuroscience, vol.34, issue.1, pp.259-288, 2011. ,
DOI : 10.1146/annurev-neuro-061010-113720
URL : http://europepmc.org/articles/pmc3192650?pdf=render
Studies on retrograde and anterograde amnesia of olfactory memory after denervation of the hippocampus by entorhinal cortex lesions, Behavioral and Neural Biology, vol.46, issue.3, pp.432-444, 1986. ,
DOI : 10.1016/S0163-1047(86)90464-4
Efficacy and safety of oral prucalopride in women with chronic constipation in whom laxatives have failed: an integrated analysis, United European Gastroenterology Journal, vol.9, issue.1, pp.48-59, 2013. ,
DOI : 10.3748/wjg.v13.i5.732
Enhanced delayed matching performance in younger and older macaques administered the 5-HT 4 receptor agonist, RS 17017, Enhanced delayed matching performance in younger and older macaques administered the 5-HT4 receptor agonist, RS 17017, pp.407-415, 1998. ,
DOI : 10.1007/s002130050529
Chronic 5-HT4 receptor activation decreases A?? production and deposition in hAPP/PS1 mice, Neurobiology of Aging, vol.34, issue.7, pp.1779-1789, 2013. ,
DOI : 10.1016/j.neurobiolaging.2013.01.020
The role of G protein-coupled receptors in the pathology of Alzheimer's disease, Nature Reviews Neuroscience, vol.156, issue.2, pp.73-87, 2011. ,
DOI : 10.1016/j.neuroscience.2008.07.042
Distribution of 5-HT4 receptors in the postmortem human brain???an autoradiographic study using [125I]SB 207710, European Neuropsychopharmacology, vol.13, issue.4, pp.228-234, 2003. ,
DOI : 10.1016/S0924-977X(03)00009-9
Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease, J Alzheimers Dis, vol.33, pp.755-766 ,
Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-?? Peptide, Journal of Alzheimer's Disease, vol.20, issue.s2, pp.527-533, 2010. ,
DOI : 10.3233/JAD-2010-100501
Naturally secreted oligomers of amyloid ?? protein potently inhibit hippocampal long-term potentiation in vivo, Nature, vol.36, issue.6880, pp.535-539, 2002. ,
DOI : 10.1021/jm00054a014
??-Secretase processing of APP inhibits neuronal activity in the hippocampus, Secretase processing of APP inhibits neuronal activity in the hippocampus, pp.443-447 ,
DOI : 10.1073/pnas.1232232100
Adult mouse astrocytes degrade amyloid-?? in vitro and in situ, Nature Medicine, vol.20, issue.4, pp.453-457, 2003. ,
DOI : 10.1038/87945
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature, Cold Spring Harbor Perspectives in Medicine, vol.2, issue.1, 2012. ,
DOI : 10.1101/cshperspect.a006346
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer???s disease, Nature Communications, vol.13, issue.1, 2015. ,
DOI : 10.1038/npp.2013.243
URL : http://www.nature.com/articles/ncomms9762.pdf