Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility

Anne Boissière (1) , Anna Gala (2, 1) , Alice Ferrières-Hoa (2, 1) , Tiffany Mullet (2, 1) , Solenne Baillet (2) , Amaël Petiton (2) , Antoine Torre (2) , Samir Hamamah (2, 1)

1 UMR 1203 - Développement embryonnaire précoce humain et pluripotence EmbryoPluripotency
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

Male infertility is a devastating problem that affects many couples worldwide. However, the molecular mechanisms and causes of idiopathic male infertility remain unclear. Circulating cell-free nucleic acids have an important role in human physiology and emerging evidence suggests that they play a role in male infertility. This review summarizes recent results on cell-free and intracellular nucleic acids in male infertility and discusses their potential use as biomarkers of male infertility in the clinical practice.

Mots clés: Seminal plasma; piRNA; biomarkers; cf-DNA; cf-mRNA; Male infertility; miRNA

Domaines: Génomique, Transcriptomique et Protéomique [q-bio.GN]; Reproduction sexuée

Anne Boissière, Anna Gala, Alice Ferrières-Hoa, Tiffany Mullet, Solenne Baillet, et al.. Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility. Basic and clinical andrology, 2017, 27, pp.7. ⟨10.1186/s12610-017-0052-0⟩. ⟨hal-01792569⟩