In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT

Peng Xiao (1) , Viacheslav Mazlin (1) , Kate Grieve (2) , José-Alain Sahel (2) , Mathias Fink (1) , A. Claude Boccara (1)

1 IL - Institut Langevin - Ondes et Images (UMR7587)
2 CHNO - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

As the lateral resolution of full-field optical coherence tomography (FFOCT) with spatially incoherent illumination has been shown to be insensitive to aberrations, we demonstrate high-resolution en face FFOCT retinal imaging without wavefront correction in the human eye in vivo for the first time, to our knowledge. A combination of FFOCT with spectral-domain OCT (SDOCT) is applied for real-time matching of the optical path lengths (OPLs) of FFOCT. Through the real-time cross-sectional SDOCT images, the OPL of the FFOCT reference arm is matched with different retinal layers in the FFOCT sample arm. Thus, diffraction-limited FFOCT images of multiple retinal layers are acquired at both the near periphery and the fovea. The en face FFOCT retinal images reveal information about various structures, such as the nerve fiber orientation, the blood vessel distribution, and the photoreceptor mosaic.

Domaines: Sciences du Vivant [q-bio]

Peng Xiao, Viacheslav Mazlin, Kate Grieve, José-Alain Sahel, Mathias Fink, et al.. In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT. Optica, 2018, 5 (4), pp.409-412. ⟨10.1364/OPTICA.5.000409⟩. ⟨hal-01788875⟩