Modulation of T Cell Activation in Obesity

Stéphanie Morin (1) , Marjorie Poggi (2) , Marie-Christine Alessi (2) , Jean-Francois Landrier (2) , Jacques Nunes (1)

1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 NORT - Nutrition, obésité et risque thrombotique

SIGNIFICANCE: Immune T cells are present in adipose tissues (AT), and the stoichiometry of the different T cell subsets is altered during diet-induced obesity (DIO). T cells contribute to the early steps of AT inflammation during DIO. Recent Advances: Many factors could potentially be responsible for this altered pro-inflammatory versus anti-inflammatory T cell balance. CRITICAL ISSUES: T cells are potentially activated in AT, which vitamin D might contribute to, as will be discussed in this article. In addition, we will review the different possible contributors to T cell activation in AT, such as the CD28 and CD154 T cell costimulatory molecules in AT. FUTURE DIRECTIONS: The potential antigen presentation capacities of adipocytes should be further investigated. Moreover, the properties of these AT resident (or migrating to AT) T cells must be further assessed. Antioxid. Redox Signal. 26, 489-500.

Mots clés: liver steatosis; CD28; T cells; costimulation; high fat diet

Domaines: Immunologie; Endocrinologie et métabolisme

Stéphanie Morin, Marjorie Poggi, Marie-Christine Alessi, Jean-Francois Landrier, Jacques Nunes. Modulation of T Cell Activation in Obesity. Antioxidants and Redox Signaling, 2017, 26 (10), pp.489-500. ⟨10.1089/ars.2016.6746⟩. ⟨hal-01788033⟩