Solving the Telomere Replication Problem

Laetitia Maestroni (1) , Samah Matmati (1) , Stéphane Coulon (1)

1 CRCM - Centre de Recherche en Cancérologie de Marseille

Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity.

Mots clés: T-loop; G-quadruplex; TERRA; telomere; telomere replication

Domaines: Sciences du Vivant [q-bio]; Génétique

Laetitia Maestroni, Samah Matmati, Stéphane Coulon. Solving the Telomere Replication Problem. Genes, 2017, 8 (2), ⟨10.3390/genes8020055⟩. ⟨hal-01787659⟩