, Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation, Molecular Cell, vol.57, issue.5, pp.769-83, 2015.
DOI : 10.1016/j.molcel.2014.12.020
URL : https://hal.archives-ouvertes.fr/hal-01110498
, Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells, Molecular and Cellular Biology, vol.27, issue.14, pp.5105-5124, 2007.
DOI : 10.1128/MCB.00162-07
URL : http://mcb.asm.org/content/27/14/5105.full.pdf
, Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia, The American Journal of Pathology, vol.175, issue.3, pp.1246-54, 2009.
DOI : 10.2353/ajpath.2009.090042
URL : http://europepmc.org/articles/pmc2731143?pdf=render
, Context-Specific Regulation of NF-??B Target Gene Expression by EZH2 in Breast Cancers, Molecular Cell, vol.43, issue.5, pp.798-810, 2011.
DOI : 10.1016/j.molcel.2011.08.011
URL : https://doi.org/10.1016/j.molcel.2011.08.011
, EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent, Science, vol.15, issue.1, pp.1465-1474, 2012.
DOI : 10.1016/j.molcel.2004.06.020
URL : http://liulab.dfci.harvard.edu/publications/Science12_1465.pdf
, EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma, Blood, vol.128, issue.7, pp.948-58, 2016.
DOI : 10.1182/blood-2016-01-690701
URL : http://www.bloodjournal.org/content/bloodjournal/128/7/948.full.pdf
, Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy, Haematologica, vol.96, issue.5, pp.712-721, 2011.
DOI : 10.3324/haematol.2010.028605
, The Polycomb group protein EZH2 is upregulated in proliferating
DOI : 10.1046/j.1365-2141.2001.02641.x
URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2001.02641.x/pdf
, Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin, Nature Genetics, vol.22, issue.2, pp.181-186, 2010.
DOI : 10.4049/jimmunol.164.1.1
URL : http://europepmc.org/articles/pmc2850970?pdf=render
, Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas, Proceedings of the National Academy of Sciences, vol.377, issue.4, pp.20980-20985, 2010.
DOI : 10.1016/j.ymeth.2003.11.016
, Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring, Annals of Hematology, vol.21, issue.6, pp.643-53, 2011.
DOI : 10.1038/sj.leu.2404796
, Diverse involvement of EZH2 in cancer epigenetics, Am J Transl Res, vol.7, pp.175-93, 2015.
, Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders, Nature Genetics, vol.8, issue.8, pp.722-728, 2010.
DOI : 10.1016/j.molcel.2008.10.016
, Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes, Nature Genetics, vol.647, issue.8, pp.665-672, 2010.
DOI : 10.1016/j.mrfmmm.2008.07.010
, Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation, Nature Communications, vol.85, p.4177, 2014.
DOI : 10.1002/path.1539
URL : http://www.nature.com/articles/ncomms5177.pdf
, Targeting of cancer stem cells by inhibitors of DNA and histone methylation, Expert Opinion on Investigational Drugs, vol.4, issue.8, pp.1031-1074, 2015.
DOI : 10.18632/oncotarget.205
, A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells, Nature Chemical Biology, vol.8, issue.11, pp.890-896, 2012.
DOI : 10.1038/nm.2651
, EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations, Nature, vol.22, issue.7427, pp.108-120, 2012.
DOI : 10.1016/0006-2952(73)90196-2
, Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation, Proceedings of the National Academy of Sciences, vol.4, issue.2, pp.21360-21365, 2012.
DOI : 10.1093/biostatistics/4.2.249
URL : http://www.pnas.org/content/109/52/21360.full.pdf
, SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2, Nature Medicine, vol.514, issue.12, pp.1491-1497, 2015.
DOI : 10.1126/science.1227604
URL : http://europepmc.org/articles/pmc4886303?pdf=render
, Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer, Cancer Cell, vol.29, issue.1, pp.17-31, 2016.
DOI : 10.1016/j.ccell.2015.12.006
URL : https://doi.org/10.1016/j.ccell.2015.12.006
, Histone m??thyltransf??rases, m??decine/sciences, vol.17, issue.8-9, pp.725-757, 2011.
DOI : 10.1016/j.bmcl.2007.05.088
, Polycomb ma??trise la destin??e cellulaire, m??decine/sciences, vol.22, issue.12, pp.1033-1038, 2006.
DOI : 10.1051/medsci/200622121033
, A ???Complex??? Issue: Deciphering the Role of Variant PRC1 in ESCs, Cell Stem Cell, vol.12, issue.2, pp.145-151, 2013.
DOI : 10.1016/j.stem.2013.01.014
, SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex, Molecular Cell, vol.15, issue.1, pp.57-67, 2004.
DOI : 10.1016/j.molcel.2004.06.020
, EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency, Molecular Cell, vol.32, issue.4, pp.491-502, 2008.
DOI : 10.1016/j.molcel.2008.10.016
URL : https://doi.org/10.1016/j.molcel.2008.10.016
, Role of PRC2-associated factors in stem cells and disease, FEBS Journal, vol.111, issue.9, pp.1723-1758, 2015.
DOI : 10.1073/pnas.1400648111
, Elements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products, Developmental Biology, vol.158, issue.1, pp.131-175, 1993.
DOI : 10.1006/dbio.1993.1174
, A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness, Cell, vol.140, issue.1, pp.99-110, 2010.
DOI : 10.1016/j.cell.2009.12.022
URL : https://doi.org/10.1016/j.cell.2009.12.022
, A Novel Human Polycomb Binding Site Acts As a Functional Polycomb Response Element in Drosophila, PLoS ONE, vol.24, issue.5, p.36365, 2012.
DOI : 10.1371/journal.pone.0036365.s002
URL : http://doi.org/10.1371/journal.pone.0036365
, Role of the polycomb protein EED in the propagation of repressive histone marks, Nature, vol.173, issue.7265, pp.762-769, 2009.
DOI : 10.1038/nature08398
, Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells, Cell, vol.125, issue.2, pp.301-314, 2006.
DOI : 10.1016/j.cell.2006.02.043
URL : https://doi.org/10.1016/j.cell.2006.02.043
, GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells, PLoS Genetics, vol.5, issue.12, p.1001244, 2010.
DOI : 10.1371/journal.pgen.1001244.s013
URL : https://doi.org/10.1371/journal.pgen.1001244
, Polycomb group protein-mediated repression of transcription, Trends in Biochemical Sciences, vol.35, issue.6, pp.323-355, 2010.
DOI : 10.1016/j.tibs.2010.02.009
, Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome, Science, vol.129, issue.5881, pp.750-756, 2008.
DOI : 10.1126/science.1157676
URL : http://europepmc.org/articles/pmc2748911?pdf=render
, Jarid2 is implicated in the initial Xistinduced targeting of PRC2 to the inactive X chromosome, Mol Cell, vol.53, pp.301-317, 2014.
, Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin, Molecular Cell, vol.53, issue.2, pp.290-300, 2014.
DOI : 10.1016/j.molcel.2013.11.012
URL : https://doi.org/10.1016/j.molcel.2013.11.012
, Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing, Science, vol.221, issue.4605, pp.1039-1082, 2002.
DOI : 10.1126/science.221.4605.23
, Hierarchical Recruitment of Polycomb Group Silencing Complexes, Molecular Cell, vol.14, issue.5, pp.637-683, 2004.
DOI : 10.1016/j.molcel.2004.05.009
URL : https://doi.org/10.1016/j.molcel.2004.05.009
, Polycomb silencers control cell fate, development and cancer, Nature Reviews Cancer, vol.116, issue.11, pp.846-56, 2006.
DOI : 10.1016/S0301-472X(00)00620-2
, Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation, Cell, vol.157, issue.6, pp.1445-59, 2014.
DOI : 10.1016/j.cell.2014.05.004
URL : https://doi.org/10.1016/j.cell.2014.05.004
, Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment, Cell Reports, vol.7, issue.5, pp.1456-70, 2014.
DOI : 10.1016/j.celrep.2014.04.012
URL : https://doi.org/10.1016/j.celrep.2014.04.012
, Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression, Nature Structural & Molecular Biology, vol.1, issue.6, pp.569-71, 2014.
DOI : 10.7554/eLife.00005
, Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells, Cancer Cell, vol.23, issue.6, pp.839-52, 2013.
DOI : 10.1016/j.ccr.2013.04.008
URL : https://doi.org/10.1016/j.ccr.2013.04.008
, EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3??Ubiquitin Ligase Complex, Molecular Cell, vol.48, issue.4, pp.572-86, 2012.
DOI : 10.1016/j.molcel.2012.09.004
URL : https://doi.org/10.1016/j.molcel.2012.09.004